Primate-specific Long Non-coding RNAs and MicroRNAs.
Primate-specific Long Non-coding RNAs and MicroRNAs.
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灵长类动物特异性长非编码 RNA 和 MicroRNA
DOI：
10.1016/j.gpb.2017.04.002
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
Shan G
中科院分区：
文献类型：
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作者：
Awan HM;Shah A;Rashid F;Shan G
非编码RNA(NcRNAs)在几乎所有的生命形式中都是基因表达的关键调节因子。长ncRNAs(LncRNAs)和microRNAs(MiRNAs)是两类重要的具有调控功能的RNA。到目前为止，已经发现和研究了许多灵长类动物特异的ncRNAs。它们对灵长类谱系的表达特异性暗示了灵长类特有的作用。因此，阐明灵长类甚至人类特有的ncRNA的生物学意义，并开发潜在的基于ncRNA的治疗方法是至关重要的。在这里，我们对一些关键的灵长类特异的lncRNAs和miRNAs的调控作用的研究进行了综述。
Non-coding RNAs (ncRNAs) are critical regulators of gene expression in essentially all life forms. Long ncRNAs (lncRNAs) and microRNAs (miRNAs) are two important RNA classes possessing regulatory functions. Up to date, many primate-specific ncRNAs have been identified and investigated. Their expression specificity to primate lineage suggests primate-specific roles. It is thus critical to elucidate the biological significance of primate or even human-specific ncRNAs, and to develop potential ncRNA-based therapeutics. Here, we have summarized the studies regarding regulatory roles of some key primate-specific lncRNAs and miRNAs.