The effects of intra-arterial vasoconstrictors on the distribution of a radiolabelled low molecular weight marker in an experimental model of liver tumour.
The effects of intra-arterial vasoconstrictors on the distribution of a radiolabelled low molecular weight marker in an experimental model of liver tumour.
复制标题
动脉内血管收缩剂对肝肿瘤实验模型中放射性标记的低分子量标记物分布的影响。
作者：
D. Hemingway;T. Cooke;D. Chang;SJ Grime;SA Jenkins
结直肠癌肝转移的区域性化疗没有显示出令人信服的生存益处超过全身化疗。这可能是由于化疗药物对少血供肝肿瘤的输送不良。由于血管活性剂可能影响肝血流量，因此本研究在肝肿瘤实验模型中研究了全身和局部血管收缩剂对局部递送标记物递送的影响。与对照组相比，血管紧张素II的全身给药导致标记物在正常肝脏中显著保留，但在肿瘤中没有。血管紧张素II和苯丙氨酸的区域递送导致肿瘤中标记物的保留显著大于肝脏，在其注射后1分钟标记物的保留总体增加4倍。注射后90分钟，与对照动物相比，标记物仍显著保留。肝动脉血管收缩剂的局部递送增加标记物的递送，并且可以增加化疗药物向肝肿瘤的递送。
Regional chemotherapy for colorectal liver metastases has not demonstrated a convincing survival benefit over systemic chemotherapy. This may be due to poor delivery of chemotherapeutic drugs to hypovascular liver tumour. Since vasoactive agents may influence hepatic blood flow this study investigated the effects of systemic and regional vasoconstrictors on the delivery of a regionally delivered marker in an experimental model of liver tumour. Systemic administration of angiotensin II caused a significant retention of marker in normal liver, but not in tumour compared to controls. Regional delivery of angiotensin II and phenylephrine caused significantly greater retention of marker in tumour than liver with an overall 4-fold increased retention of marker one minute after its injection. Ninety minutes after injection there was still significant retention of marker compared to control animals. Regional delivery of hepatic artery vasoconstrictors increase delivery of marker and may increase delivery of chemotherapeutic drug to liver tumour.