Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
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DOI：
10.1152/ajpregu.00604.2003
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发表时间：
2004-07-01
影响因子：
2.8
通讯作者：
Baskin, DG
中科院分区：
文献类型：
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作者：
Blevins, JE;Schwartz, MW;Baskin, DG
小细胞室旁核（pPVN）中催产素神经元的后脑投射被假设为将瘦素信号从下丘脑传递到孤束核（NTS），其中接收来自胃肠道的饱腹感信号。使用免疫细胞化学，我们发现，厌食剂量的瘦素给药到第三脑室（3V）增加了两倍的pPVN催产素神经元表达Fos的数量。将荧光霍乱毒素B注射到NTS中标记了pPVN催产素神经元的一个子集，该神经元响应于3V瘦素而表达Fos。此外，3V给药催产素受体拮抗剂[D-（CH 2）5，Tyr（Me）2，Orn 8]-vasotocin（OVT）在0.5- 4小时内减弱了瘦素对摄食的影响（P
Hindbrain projections of oxytocin neurons in the parvocellular paraventricular nucleus (pPVN) are hypothesized to transmit leptin signaling from the hypothalamus to the nucleus of the solitary tract (NTS), where satiety signals from the gastrointestinal tract are received. Using immunocytochemistry, we found that an anorectic dose of leptin administered into the third ventricle (3V) increased twofold the number of pPVN oxytocin neurons that expressed Fos. Injections of fluorescent cholera toxin B into the NTS labeled a subset of pPVN oxytocin neurons that expressed Fos in response to 3V leptin. Moreover, 3V administration of an oxytocin receptor antagonist, [D-(CH2)5, Tyr(Me)2, Orn8]-vasotocin (OVT), attenuated the effect of leptin on food intake over a 0.5- to 4-h period (P