Social isolation-induced aggression potentiates anxiety and depressive-like behavior in male mice subjected to unpredictable chronic mild stress.
Social isolation-induced aggression potentiates anxiety and depressive-like behavior in male mice subjected to unpredictable chronic mild stress.
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社会孤立引起的攻击会加剧遭受不可预测的慢性轻度压力的雄性小鼠的焦虑和抑郁样行为
DOI：
10.1371/journal.pone.0020955
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Gao CG
中科院分区：
文献类型：
--
作者：
Ma XC;Jiang D;Jiang WH;Wang F;Jia M;Wu J;Hashimoto K;Dang YH;Gao CG
背景大量流行病学证据表明，生活事件应激源是抑郁症等精神疾病的主要易感因素。众所周知，雄性小鼠的社会隔离会导致攻击性行为。然而，目前尚不清楚社会隔离诱导的攻击如何影响孤立的雄性小鼠的焦虑和抑郁样行为，这些小鼠受到不可预测的慢性轻度应激（CMS），这是一种抑郁症的动物模型。方法学/主要发现将C57/B6雄性小鼠分为3组;非应激对照组，第I组;接受CMS方案的隔离小鼠，第II组;接受CMS方案的社交隔离小鼠，第III组通过身体接触进行攻击。在蔗糖摄入试验中，第II组和第III组小鼠摄入1%蔗糖溶液的量显著低于第I组。此外，第III组小鼠中该溶液的摄入量显著低于第II组小鼠。在旷场试验中，与第I组和第II组小鼠相比，第III组小鼠显示出减少的运动活动以及减少的进入和保留时间。此外，第III组小鼠在1小时内移动的距离在夜间和早晨之间没有差异。在光/黑盒试验中，与组I动物相比，组II和组III动物在光盒中花费的时间显著更少。在悬尾试验（TST）和强迫游泳试验（FST）中，II组和III组小鼠的不动时间显著长于I组小鼠。此外，第III组小鼠在FST中的不动时间显著长于第II组小鼠。结论/意义这些发现表明，社会隔离诱导的攻击行为可以加强隔离雄性小鼠遭受CMS的焦虑和抑郁样行为。
Background Accumulating epidemiological evidence shows that life event stressors are major vulnerability factors for psychiatric diseases such as major depression. It is also well known that social isolation in male mice results in aggressive behavior. However, it is not known how social isolation-induced aggression affects anxiety and depressive-like behavior in isolated male mice subjected to unpredictable chronic mild stress (CMS), an animal model of depression. Methodology/Principal Findings C57/B6 male mice were divided into 3 groups; non-stressed controls, in Group I; isolated mice subjected to the CMS protocol in Group II and aggression by physical contact in socially isolated mice subjected to the CMS protocol in Group III. In the sucrose intake test, ingestion of a 1% sucrose solution by mice in Groups II and III was significantly lower than in Group I. Furthermore, intake of this solution in Group III mice was significantly lower than in Group II mice. In the open field test, mice in Group III, showed reduced locomotor activity and reduced entry and retention time in the central zone, compared to Groups I and II mice. Moreover, the distances moved in 1 hour by Group III mice did not differ between night and morning. In the light/black box test, Groups II and III animals spent significantly less time in the light box compared to Group I animals. In the tail suspension test (TST) and forced swimming test (FST), the immobility times of Group II and Group III mice were significantly longer than in Group I mice. In addition, immobility times in the FST were significantly longer in Group III than in Group II mice. Conclusions/Significance These findings show that social isolation-induced aggression could potentiate anxiety and depressive -like behaviors in isolated male mice subjected to CMS.
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影响因子：
17.7
作者：
Kendler, KS;Karkowski, LM;Prescott, CA
通讯作者：
Prescott, CA
影响因子：
2.7
作者：
CRUSIO, WE;SCHWEGLER, H
通讯作者：
SCHWEGLER, H
影响因子：
6.6
作者：
Holsboer, F
通讯作者：
Holsboer, F
影响因子：
10.6
作者：
Li, Nanxin;Liu, Rong-Jian;Dwyer, Jason M.;Banasr, Mounira;Lee, Boyoung;Son, Hyeon;Li, Xiao-Yuan;Aghajanian, George;Duman, Ronald S.
通讯作者：
Duman, Ronald S.
影响因子：
3.6
作者：
KATZ, RJ
通讯作者：
KATZ, RJ