Auditory cortical generators of the Frequency Following Response are modulated by intermodal attention
Auditory cortical generators of the Frequency Following Response are modulated by intermodal attention
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DOI：
10.1016/j.neuroimage.2019.116185
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发表时间：
2019-12-01
期刊：
影响因子：
5.7
通讯作者：
Weisz, Nathan
中科院分区：
文献类型：
--
作者：
Hartmann, Thomas;Weisz, Nathan
传出听觉系统表明脑干听觉区域也可能对自上而下的过程敏感。在电生理学中，对语音刺激的频率跟随反应（FFR）已被广泛用于研究脑干区域。尽管通过FFR来解决脑干区域的注意力调节问题似乎是直截了当的，但现有的结果是不一致的。此外，血流储备分数仅代表皮质下发生器的观点受到质疑。我们的目的是获得一个更有区别的角度来看，如何通过关注视觉或听觉输入调制FFR的发生器，同时使用脑磁图（MEG）记录神经活动。在第一步中，我们的结果证实了皮质区域对FFR的强大贡献。有趣的是，在所有表现出可测量FFR反应的区域中，只有右侧初级听觉皮层受到通道间注意的显著影响。通过显示大脑皮层对注意力血流储备分数效应的明显贡献，我们的工作显著扩展了以前仅关注表面水平记录的报告。它强调了更加努力地理清FFR的不同贡献来源的重要性，并作为将FFR简单解释为脑干反应的明确预防措施。
The efferent auditory system suggests that brainstem auditory regions could also be sensitive to top-down processes. In electrophysiology, the Frequency Following Response (FFR) to speech stimuli has been used extensively to study brainstem areas. Despite seemingly straight-forward in addressing the issue of attentional modulations of brainstem regions by means of the FFR, the existing results are inconsistent. Moreover, the notion that the FFR exclusively represents subcortical generators has been challenged. We aimed to gain a more differentiated perspective on how the generators of the FFR are modulated by either attending to the visual or auditory input while neural activity was recorded using magnetoencephalography (MEG). In a first step our results confirm the strong contribution of also cortical regions to the FFR. Interestingly, of all regions exhibiting a measurable FFR response, only the right primary auditory cortex was significantly affected by intermodal attention. By showing a clear cortical contribution to the attentional FFR effect, our work significantly extends previous reports that focus on surface level recordings only. It underlines the importance of making a greater effort to disentangle the different contributing sources of the FFR and serves as a clear precaution of simplistically interpreting the FFR as brainstem response.