TRANSCRANIAL DOPPLER ULTRASOUND IN HYPERTENSIVE VERSUS NORMOTENSIVE PATIENTS AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE
TRANSCRANIAL DOPPLER ULTRASOUND IN HYPERTENSIVE VERSUS NORMOTENSIVE PATIENTS AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE
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DOI：
10.1161/01.str.26.11.2071
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发表时间：
1995-11-01
期刊：
影响因子：
8.3
通讯作者：
BRANDT, L
中科院分区：
文献类型：
--
作者：
EKELUND, A;SAVELAND, H;BRANDT, L
背景与目的动脉高压是动脉瘤性蛛网膜下腔出血(SAH)后的负性预后危险因素。经颅多普勒超声是预测蛛网膜下腔出血后血管痉挛所致脑缺血的常用方法。目的探讨动脉高压对动脉瘤性蛛网膜下腔出血(SAH)后脑循环血流速度的影响。方法应用经颅多普勒超声对高血压和正常血压的动脉瘤性SAH患者的脑血流速度进行比较。在为期两周的时间里，24名动脉高血压患者每天接受检查。结果高血压患者大脑中动脉的最小血流速度、平均血流速度和最大血流速度均显著低于正常血压组，P=0.02，P=0.02。这些组的搏动指数差异无统计学意义(P=.45)。2例高血压病患者和6例血压正常的患者出现舒张期切迹。结论高血压病患者即使血流速度轻度增加，也可能表现为明显的血管痉挛。
Background and Purpose Arterial hypertension is a negative prognostic risk factor after aneurysmal subarachnoid hemorrhage (SAH). Transcranial Doppler ultrasound is commonly used for measuring blood flow velocities to predict cerebral ischemia due to vasospasm after SAH. Our purpose was to evaluate the influence of arterial hypertension on blood flow velocities in the cerebral circulation after aneurysmal SAH.Methods With transcranial Doppler ultrasound we compared the brood flow velocities in matched groups of hypertensive and normotensive patients with aneurysmal SAH. Twenty-four patients with arterial hypertension were examined daily during a 2-week period. As controls, 24 normotensive patients, also with SAH, were matched by age, sex, neurological status, and clinical outcome.Results Minimum, mean and maximum flow velocities in the middle cerebral artery in the hypertensive patients were significantly lower than in the normotensive individuals, with P=.02 for minimum, P=.02 for mean, and P=.02 for maximum. There was no statistical significance for pulsatility index differences in these groups (P=.45). Diastolic notch was noted in two of the hypertensive and in six of the normotensive patients.Conclusions The results indicate that even moderately increased flow velocities in hypertensive patients may represent significant vasospasm.