FACTORS INFLUENCING PROGRESSION IN PATIENTS WITH CHRONIC RENAL-FAILURE
FACTORS INFLUENCING PROGRESSION IN PATIENTS WITH CHRONIC RENAL-FAILURE
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DOI：
10.1111/j.1365-2796.1989.tb01377.x
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发表时间：
1989-09-01
影响因子：
11.1
通讯作者：
BERGSTROM, J
中科院分区：
文献类型：
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作者：
STENVINKEL, P;ALVESTRAND, A;BERGSTROM, J
为了确定影响非糖尿病患者中慢性肾衰竭（CRF）的进展速率的因素，回顾性地审查了1980-86年期间124名患有已确定的CRF的患者的病历（在随访开始时血清肌酐在200-350 μ mol l-1之间）。16例患者因不符合入选标准而被排除。其余108例患者根据其原始诊断分为四组，并被分配到三组中的一组，以表达其进展率。这些进展率的定义是任意选择的。比较两组平均动脉压（MAP）、尿蛋白排泄量（UPE）及CRF进展率。在CRF无进展组（n = 17）中，MAP和UPE显著低于两个进展组。在所有患者和不同诊断组中，UPE与CRF进展率之间存在很强的相关性。各诊断组的MAP与CRF进展率无明显相关性。这些结果表明，蛋白尿的增加幅度是一个不利的预后因素，在CRF，无论病因，并支持认为，过度肾小球蛋白过滤导致肾小球硬化症。
To identify factors influencing the progression rate of chronic renal failure (CRF) in non-diabetics, the medical records of 124 patients with established CRF were reviewed retrospectively (serum creatinine between 200-350 .mu.mol l-1 at the start of follow-up) for the period 1980-86. Sixteen patients were excluded because they did not fulfill the inclusion criteria. The remaining 108 patients were divided, using their original diagnosis, into four groups and were also assigned into one of three groups expressing their rate of progression. The definitions of these rates of progression were chosen arbitrarily. Comparisons with respect to mean arterial pressure (MAP), urinary protein excretion (UPE) and the progression rate of CRF were then made between the groups. In the group showing no progression of CRF (n = 17) there was a significantly lower MAP and UPE than in the two groups showing progression. Over all the patients and in the various diagnosis groups there was a strong correlation between UPE and the progression rate of CRF. There was no significant correlation between MAP and the progression rate of CRF in the diagnosis groups. These results indicate that an increasing magnitude of proteinuria is an adverse prognostic factor in CRF, irrespective of aetiology, and support the view that excessive glomerular protein filtration leads to glomerulosclerosis.