A dose-response evaluation of freeze-dried strawberries independent of fiber content on metabolic indices in abdominally obese individuals with insulin resistance in a randomized, single-blinded, diet-controlled crossover trial
A dose-response evaluation of freeze-dried strawberries independent of fiber content on metabolic indices in abdominally obese individuals with insulin resistance in a randomized, single-blinded, diet-controlled crossover trial
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DOI：
10.1002/mnfr.201500845
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发表时间：
2016-05-01
影响因子：
5.2
通讯作者：
Burton-Freeman, Britt
中科院分区：
文献类型：
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作者：
Park, Eunyoung;Edirisinghe, Indika;Burton-Freeman, Britt
适用范围：本研究评估了草莓（一种富含花青素的水果）对胰岛素抵抗（IR）患者餐后血糖和胰岛素浓度的剂量反应关系，包括血浆花青素、氧化应激标志物和炎症的变化。方法和结果：在一项随机对照、四臂、剂量反应、交叉试验中，21名IR成人摄入高碳水化合物，高脂肪膳食与含有0 g冻干全草莓粉（0 g FDS，对照）、10、20或40 g FDS的四种饮料之一，控制纤维。在餐后0 min和30 min间隔采集血液，直至2 h，然后每小时采集一次，直至6 h。与其他饮料相比，40 g FDS饮料后餐后胰岛素浓度（6 h）显著降低（p < 0.05）。餐后6小时葡萄糖浓度没有差异，尽管平均胰岛素：葡萄糖比率在饮料之间有显著差异（p < 0.05）。天竺葵素-葡糖苷酸与20和40 g FDS后的平均胰岛素浓度呈负相关（p < 0.05）。20 g FDS后氧化低密度脂蛋白降低（p < 0.05），IL-6在治疗组间无差异。草莓的摄入量减少了胰岛素的需求，以管理餐后葡萄糖的肥胖个体与IR，这是相关的血浆花青素/天竺葵色素concentrations.Conclusion：数据支持的作用，草莓在改善胰岛素敏感性的人与IR。
Scope: This study evaluated the dose-response relationship of strawberries, an anthocyanin-rich fruit, on postprandial glucose and insulin concentrations in individuals with insulin resistance (IR), including changes in plasma anthocyanins, markers of oxidative stress, and inflammation.Methods and Results: In a randomized controlled, four-arm, dose-response, crossover trial, 21 adults with IR consumed a high-carbohydrate, high-fat meal with one of four beverages containing 0 g freeze-dried whole strawberry powder (0g FDS, control), 10, 20, or 40 g FDS, controlled for fiber. Blood was collected at 0 min and at 30 min intervals postmeal until 2 h, then hourly until 6 h. Postmeal insulin concentrations (6 h) were significantly reduced after the 40-g FDS beverage compared to other beverages (p < 0.05). Postmeal 6 h glucose concentrations were not different, although mean insulin:glucose ratio was significantly different among beverages (p < 0.05). Pelargonidin-glucuronide was inversely associated with mean insulin concentrations after the 20 and 40 g FDS (p < 0.05). Oxidized low-density lipoprotein was reduced after 20 g FDS (p < 0.05) and IL-6 was not different among treatments. Strawberry intake reduced the insulin demand to manage postmeal glucose in obese individuals with IR, which was related to plasma anthocyanin/pelargonidin concentrations.Conclusion: The data support a role of strawberries in improving insulin sensitivity in people with IR.