VENTILATION AND AROUSAL RESPONSES TO HYPERCAPNIA IN NORMAL SLEEPING HUMANS
VENTILATION AND AROUSAL RESPONSES TO HYPERCAPNIA IN NORMAL SLEEPING HUMANS
复制标题
DOI：
10.1152/jappl.1984.57.1.59
复制
发表时间：
1984-01-01
影响因子：
3.3
通讯作者：
SULLIVAN, CE
中科院分区：
文献类型：
--
作者：
BERTHONJONES, M;SULLIVAN, CE
从一个小袋子中重新呼吸的唤醒和净化反应，最初。7%CO_2在40%O_2中，通过鼻罩在13名正常成人中测量。随着非快速眼动睡眠（NREM）的加深，男性在肺泡PCO 2增加时觉醒（平均值± 0.01）。SE：II期58.6 ±。1.7，第三阶段61.2 .+-。1.0，第四阶段63.8 .+-。0.8 Torr），而在快速眼动睡眠（REM）中，唤醒肺泡PCO 2为57.7 ± 0.01。0.7托，即，远低于第三阶段和第四阶段NREM。女性在觉醒肺泡PCO 2中没有显示出显著变化，（II 57.6 . ±. 0.9，III 57.3 .+-。1.3，IV 59.4 .+-。0.9，REM 56.3 ±。1.0 Torr）。男性的排泄反应为2.5 ±-。0.1（SE）1. min-1. Torr-1，在NREM中下降了49%（1.29 ± 0.01）。0.13）和69%的REM（0.78 ±。0.18）。女性的反应受状态的影响很小，与男性的NREM反应相似（清醒时为1.39 ± 0.01）。0.14，非快速眼动1.40 ±。0.13，REM 1.11 .+-。0.26 l. cntdot. min-1.托-1）。在NREM测试中，睡眠状态没有变化，直到觉醒，而在REM中，受试者突然醒来与再呼吸的开始（11例），表现出短暂的觉醒与发作，但继续在REM，直到最后觉醒（21例）或改变为NREM发作（2例）。这些觉醒结果与气管造口犬和阻塞性睡眠呼吸暂停综合征的结果形成鲜明对比，其中REM中的窒息性觉醒晚于NREM，这表明REM中测试开始时的事件可能与REM特定的上气道对CO2的敏感性有关。
Arousal and ventilatory responses to rebreathing from a small bag, initially .apprx. 7% CO2 in 40% O2, were measured via a nose mask in 13 normal human adults. With deepening non-rapid-eye-movement sleep (NREM), males aroused at increasing alveolar PCO2 (mean .+-. SE: stage II 58.6 .+-. 1.7, stage III 61.2 .+-. 1.0, stage IV 63.8 .+-. 0.8 Torr), whereas in rapid-eye-movement sleep (REM), arousal alveolar PCO2 was 57.7 .+-. 0.7 Torr, i.e., much lower than in stage III and IV NREM. Females showed no significant change in arousal alveolar PCO2, (II 57.6 .+-. 0.9, III 57.3 .+-. 1.3, IV 59.4 .+-. 0.9, REM 56.3 .+-. 1.0 Torr). Male ventilatory response was 2.5 .+-. 0.1 (SE) 1 .cntdot. min-1 .cntdot. Torr-1 and fell by 49% in NREM (1.29 .+-. 0.13) and by 69% in REM (0.78 .+-. 0.18). Female response was little affected by state, being similar to male NREM response (wake 1.39 .+-. 0.14, NREM 1.40 .+-. 0.13, REM 1.11 .+-. 0.26 l .cntdot. min-1 .cntdot. Torr-1). In NREM tests, there was no change in sleep state until arousal, whereas in REM, subjects awoke abruptly with the onset of rebreathing (11 cases), showed a transient arousal with onset but continued in REM until final arousal (21 cases) or changed to NREM at onset (2 cases). These arousal results contrast sharply with findings in tracheostomized dogs and in obstructive sleep apnea syndrome, where asphyxic arousal is later in REM than in NREM, suggesting that the events at test onset in REM may be related to upper airway sensitivity to CO2 specific to REM.