The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
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DOI：
10.1038/ng.3667
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发表时间：
2016-10
期刊：
影响因子：
30.8
通讯作者：
Munroe, Patricia B.
中科院分区：
文献类型：
--
作者：
Ehret, Georg B.;Ferreira, Teresa;Chasman, Daniel I.;Jackson, Anne U.;Schmidt, Ellen M.;Johnson, Toby;Thorleifsson, Gudmar;Luan, Jian'an;Donnelly, Louise A.;Kanoni, Stavroula;Petersen, Ann -Kristin;Pihurl, Vasyl;Strawbridge, Rona J.;Shungin, Dmitry;Hughes, Maria F.;Meirelles, Osorio;Kaakinen, Marika;Bouatia-Naji, Nabila;Kristiansson, Kati;Shah, Sonia;Kleber, Marcus E.;Guo, Xiuqing;Lyytikainen, Leo-Pekka;Fava, Cristiano;Eriksson, Nidas;Nolte, Ilja M.;Magnusson, Patrik K.;Salfati, Elias L.;Rallidis, Loukianos S.;Theusch, Elizabeth;Smith, Andrew J. P.;Folkersen, Lasse;Witkowska, Kate;Pers, Tune H.;Joehanes, Roby;Kim, Stuart K.;Lataniotis, Lazaros;Jansen, Rick;Johnson, Andrew D.;Warren, Helen;Kim, Young Jin;Zhao, Wei;Wu, Ying;Tayo, Bamidele O.;Bochud, Murielle;Absher, Devin;Adair, Linda S.;Amin, Najaf;Arkingl, Dan E.;Axelsson, Tomas;Baldassarre, Damian;Balkau, Beverley;Bandinelli, Stefania;Barnes, Michael R.;Barroso, Ines;Bevan, Stephen;Bis, Joshua C.;Bjornsdottir, Gyda;Boehnke, Michael;Boerwinkle, Eric;Bonnycastle, Lori L.;Boomsma, Dorret I.;Bornstein, Stefan R.;Brown, Morris J.;Burnier, Michel;Cabrera, Claudia P.;Chambers, John C.;Chang, I-Shou;Cheng, Ching-Yu;Chines, Peter S.;Chung, Ren-Hua;Collins, Francis S.;Connell, John M.;Doring, Angela;Dallongeville, Jean;Danesh, John;de Faire, Ulf;Delgado, Graciela;Dominiczak, Anna F.;Doney, Alex S. F.;Drenos, Fotios;Edkins, Sarah;Eicher, John D.;Elosua, Roberto;Enroth, Stefan;Erdmann, Jeanette;Eriksson, Per;Esko, Tonu;Evangelou, Evangelos;Evans, Alun;Fai, Tove;Farra, Martin;Felixl, Janine F.;Ferrieres, Jean;Ferrucci, Luigi;Fornage, Myriam;Forrester, Terrence;Franceschinil, Nora;Franco, Oscar H.;Franco-Cereceda, Anders;Fraser, Ross M.;Ganesh, Santhi K.;Gao, He;Gertow, Karl;Gianfagna, Francesco;Gigante, Bruna;Giulianini, Franco;Goe, Anuj;Goodall, Alison H.;Goodarzi, Mark;Gorski, Mathias;Grassler, Jurgen;Groves, Christopher J.;Gudnason, Vilmundur;Gyllensten, Ulf;Hallmans, Goran;Hartikainen, Anna-Liisa;Hassinen, Maija;Havulinna, Aki S.;Hayward, Caroline;Hercberg, Serge;Herzig, Karl-Heinz;Hicks, Andrew A.;Hingorani, Aroon D.;Hirschhorn, Joel N.;Hofmanl, Albert;Holmen, Jostein;Holmen, Oddgeir Lingaas;Hottenga, Jouke-Jan;Howard, Phil;Hsiung, Chao A.;Hunt, Steven C.;Ikram, M. Arfan;Illig, Thomas;Iribarren, Carlos;Jensen, Richard A.;Kahonen, Mika;Kang, Hyun Min;Kathiresan, Sekar;Keating, Brendan J.;Khaw, Kay-Tee;Kim, Yun Kyoung;Kim, Eric;Kivimaki, Mika;Klopp, Norman;Kolovou, Genovefa;Komulainen, Pirjo;Kooner, Jaspal S.;Kosova, Gulum;Krauss, Ronald M.;Kuh, Diana;Kutalik, Zoltan;Kuusisto, Johanna;Kvaloy, Kirsti;Lakka, Timo A.;Lee, Nanette R.;Lee, I-Te;Lee, Wen-Jane;Levy, Daniel;Li, Xiaohui;Liang, Kae-Woei;Lin, Honghuang;Lin, Li;Lindstrom, Jaana;Lobbens, Stephane;Mannisto, Satu;Muller, Gabriele;Muller-Nurasyid, Martina;Mach, Francois;Markus, Hugh S.;Marouli, Eirini;McCarthy, Mark I.;McKenzie, Colin A.;Meneton, Pierre;Menni, Cristina;Metspalu, Andres;Mijatovic, Vladan;Moilanen, Leena;Montasser, May E.;Morris, Andrew D.;Morrison, Alanna C.;Mulas, Antonella;Nagaraja, Ramaiah;Narisu, Narisu;Nikus, Kjell;O'Donnell, Christopher J.;O'Reilly, Paul F.;Ong, Ken K.;Paccaud, Fred;Palmer, Cameron D.;Parsa, Afshin;Pedersen, Nancy L.;Penninx, Brenda W.;Perola, Markus;Peters, Annette;Poulter, Neil;Pramstaller, Peter P.;Psaty, Bruce M.;Quertermous, Thomas;Rao, Dabeeru C.;Rasheed, Asif;Rayner, N. William;Renstrom, Frida;Rettig, Rainer;Rice, Kenneth M.;Roberts, Robert;Rose, Lynda M.;Rossouw, Jacques;Samani, Nilesh J.;Sanna, Serena;Saramies, Jouko;Schunkert, Heribert;Sebert, Sylvain;Sheu, Wayne H-H;Shin, Young-Ah;Sim, Xueling;Smit, Johannes H.;Smith, Albert V.;Sosa, Maria X.;Spector, Tim D.;Stancakova, Alena;Stanton, Alice V.;Stirrups, Kathleen E.;Stringham, Heather M.;Sundstrom, Johan;Swift, Amy J.;Syvanen, Ann-Christine;Tai, E-Shyong;Tanaka, Toshiko;Tarasov, Kirill V.;Teumer, Alexander;Thorsteinsdottir, Unnur;Tobin, Martin D.;Tremoli, Elena;Uitterlinden, Andre G.;Uusitupa, Matti;Vaez, Ahmad;Vaidya, Dhananjay;van Duijn, Cornelia M.;van Iperen, Erik P. A.;Vasan, Ramachandran S.;Verwoert, Germaine C.;Virtamo, Jarmo;Vitart, Veronique;Voight, Benjamin F.;Vollenweider, Peter;Wagner, Aline;Wain, Louise V.;Wareham, Nicholas J.;Watldns, Hugh;Weder, Alan B.;Westra, Harm Jan;Wilks, Rainford;Wilsgaard, Tom;Wilson, James F.;Wong, Tien Y.;Yang, Tsun-Po;Yao, Jie;Yengo, Loic;Zhang, Weihua;Zhao, Jing Hua;Zhu, Xiaofeng;Bovet, Pascal;Cooper, Richard S.;Mohlke, Karen L.;Saleheen, Danish;Lee, Jong-Young;Elliott, Paul;Gierman, Hinco J.;Willer, Cristen J.;Franke, Lude;Hovingh, G. Kees;Taylor, Kent D.;Dedoussis, George;Sever, Peter;Wong, Andrew;Lind, Lars;Assimes, Themistocles L.;Njolstad, Inger;Schwarz, Peter E. H.;Langenberg, Claudia;Snieder, Harold;Caulfield, Mark J.;Melander, E.;Laakso, Markku;Saltevo, Juha;Rauramaa, Rainer;Tuomilehto, Jaakko;Ingelsson, Erik;Lehtimaki, Terho;Hveem, Kristian;Palmas, Walter;Marz, Winfried;Kumar, Meena;Salomaa, Veikko;Chen, Yii-Der I.;Rotter, Jerome I.;Froguel, Philippe;Jarvelin, Marjo-Riitta;Lakatta, Edward G.;Kuulasmaa, Kari;Franks, Paul W.;Hamsten, Anders;Wichmann, H-Erich;Palmer, Colin N. A.;Stefansson, Kari;Ridker, Paul M.;Loos, Ruth J. F.;Chalcravarti, Aravinda;Deloukas, Panos;Morris, Andrew P.;Newton-Cheh, Christopher;Munroe, Patricia B.
为了剖析血压的遗传结构并评估对靶器官损伤的影响，我们分析了来自201，529名欧洲血统个体的靶向和全基因组阵列的128，272个SNP，并使用来自另外140，886名个体的基因型进行验证。我们确定了66个血压位点，其中17个是新的，15个具有多个不同的关联信号。66个索引SNP富含顺式调节元件，特别是在血管内皮细胞中，这与通过调节多个组织的血管张力来控制血压的主要作用一致。在64，421名非欧洲血统的个体中，66个指数SNP组合在风险评分中显示出相当的效果。66-SNP血压风险评分与多个组织的靶器官损伤显著相关，对肾脏的影响较小。我们的发现扩展了目前对血压通路的认识，并突出了血压调节中经典肾脏系统以外的组织。
To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure loci, of which 17 were novel and 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target-organ damage in multiple tissues, with minor effects in the kidney. Our findings expand current knowledge of blood pressure pathways and highlight tissues beyond the classic renal system in blood pressure regulation.
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影响因子：
64.8
作者：
Ernst, Jason;Kheradpour, Pouya;Mikkelsen, Tarjei S.;Shoresh, Noam;Ward, Lucas D.;Epstein, Charles B.;Zhang, Xiaolan;Wang, Li;Issner, Robbyn;Coyne, Michael;Ku, Manching;Durham, Timothy;Kellis, Manolis;Bernstein, Bradley E.
通讯作者：
Bernstein, Bradley E.
影响因子：
64.8
作者：
Shungin, Dmitry;Winkler, Thomas W.;Croteau-Chonka, Damien C.;Ferreira, Teresa;Lockes, Adam E.;Maegi, Reedik;Strawbridge, Rona J.;Pers, Tune H.;Fischer, Krista;Justice, Anne E.;Workalemahu, Tsegaselassie;Wu, Joseph M. W.;Buchkovich, Martin L.;Heard-Costa, Nancy L.;Roman, Tamara S.;Drong, Alexander W.;Song, Ci;Gustafsson, Stefan;Day, Felix R.;Esko, Tonu;Fall, Tove;Kutalik, Zoltan;Luan, Jian'an;Randall, Joshua C.;Scherag, Andre;Vedantam, Sailaja;Wood, Andrew R.;Chen, Jin;Fehrmann, Rudolf;Karjalainen, Juha;Kahali, Bratati;Liu, Ching-Ti;Schmidt, Ellen M.;Absher, Devin;Amin, Najaf;Anderson, Denise;Beekman, Marian;Bragg-Gresham, Jennifer L.;Buyske, Steven;Demirkan, Ayse;Ehret, Georg B.;Feitosa, Mary F.;Goel, Anuj;Jackson, Anne U.;Johnson, Toby;Kleber, Marcus E.;Kristiansson, Kati;Mangino, Massimo;Leach, Irene Mateo;Medina-Gomez, Carolina;Palmer, Cameron D.;Pasko, Dorota;Pechlivaniss, Sonali;Peters, Marjolein J.;Prokopenko, Inga;Stancakova, Alena;Sung, Yun Ju;Tanakam, Toshiko;Teumer, Alexander;Van Vliet-Ostaptchouk, Jana V.;Yengo, Loic;Zhang, Weihua;Albrecht, Eva;Arnlov, Johan;Arscott, Gillian M.;Bandinelli, Stefania;Barrett, Amy;Bellis, Claire;Bennett, Amanda J.;Berne, Christian;Blueher, Matthias;Buhringer, Stefan;Bonnet, Fabrice;Boettcher, Yvonne;Bruinenberg, Marcel;Carba, Delia B.;Caspersen, Ida H.;Clarke, Robert;Daw, E. Warwick;Deelen, Joris;Deelman, Ewa;Delgado, Graciela;Doney, Alex S. F.;Eklund, Niina;Erdos, Michael R.;Estrada, Karol;Eury, Elodie;Friedrichs, Nele;Garcia, Melissa E.;Giedraitis, Vilmantas;Gigante, Bruna;Go, Alan S.;Golay, Alain;Grallert, Harald;Grammer, Tanja B.;Graessler, Juergen;Grewal, Jagvir;Groves, Christopher J.;Haller, Toomas;Hallmans, Goran;Hartman, Catharina A.;Hassinen, Maija;Hayward, Caroline;Heikkila, Kauko;Herzig, Karl-Heinz;Helmer, Quinta;Hillege, Hans L.;Holmen, Oddgeir;Hunt, Steven C.;Isaacs, Aaron;Ittermann, Till;James, Alan L.;Johansson, Ingegerd;Juliusdottir, Thorhildur;Kalafati, Ioanna-Panagiota;Kinnunen, Leena;Koenig, Wolfgang;Kooner, Ishminder K.;Kratzer, Wolfgang;Lamina, Claudia;Leander, Karin;Lee, Nanette R.;Lichtner, Peter;Lind, Lars;Lindstrom, Jaana;Lobbens, Stephane;Lorentzon, Mattias;Mach, Francois;Magnusson, Patrik K. E.;Mahajan, Anubha;McArdle, Wendy L.;Menni, Cristina;Merger, Sigrun;Mihailov, Evelin;Milani, Lili;Mills, Rebecca;Moayyeri, Alireza;Monda, Ken L.;Mooijaart, Simon P.;Muehleisen, Thomas W.;Mulas, Antonella;Mueller, Gabriele;Mueller-Nurasyid, Martina;Nagaraja, Ramaiah;Nalls, Michael A.;Narisu, Narisu;Glorioso, Nicola;Nolte, Ilja M.;Olden, Matthias;Rayner, Nigel W.;Renstrom, Frida;Ried, Janina S.;Robertson, Neil R.;Rose, Lynda M.;Sanna, Serena;Scharnagl, Hubert;Scholtens, Salome;Sennblad, Bengt;Seufferlein, Thomas;Sitlani, Colleen M.;Smith, Albert Vernon;Stirrups, Kathleen;Stringham, Heather M.;Sundstrom, Johan;Swertz, Morris A.;Swift, Amy J.;Syvanen, Ann-Christine;Tayo, Bamidele O.;Thorand, Barbara;Thorleifsson, Gudmar;Tomaschitz, Andreas;Troffa, Chiara;van Oort, Floor V. A.;Verweij, Niek;Vonk, Judith M.;Waite, Lindsay L.;Wennauer, Roman;Wilsgaard, Tom;Wojczynski, Mary K.;Wong, Andrew;Zhang, Qunyuan;Zhao, Jing Hua;Brennan, Eoin P.;Choi, Murim;Eriksson, Per;Folkersen, Lasse;Franco-Cereceda, Anders;Gharavi, Ali G.;Hedman, Asa K.;Hivert, Marie-France;Huang, Jinyan;Kanoni, Stavroula;Karpe, Fredrik;Keildson, Sarah;Kiryluk, Krzysztof;Liang, Liming;Lifton, Richard P.;Ma, Baoshan;McKnight, Amy J.;McPherson, Ruth;Metspalu, Andres;Min, Josine L.;Moffatt, Miriam F.;Montgomery, Grant W.;Murabito, Joanne M.;Nicholson, George;Nyholt, Dale R.;Olsson, Christian;Perry, John R. B.;Reinmaa, Eva;Salem, Rany M.;Sandholm, Niina;Schadt, Eric E.;Scott, Robert A.;Stolk, Lisette;Vallejo, Edgar E.;Westra, Harm-Jan;Zondervan, Krina T.;Amouyel, Philippe;Arveiler, Dominique;Bakker, Stephan J. L.;Beilby, John;Bergman, Richard N.;Blangero, John;Brown, Morris J.;Burnier, Michel;Campbell, Harry;Chakravarti, Aravinda;Chiness, Peter S.;Claudi-Boehmi, Simone;Collins, Francis S.;Crawford, Dana C.;Danesh, John;de Faire, Ulf;de Geusl, Eco J. C.;Doerr, Marcus;Erbel, Raimund;Eriksson, Johan G.;Farrall, Martin;Ferrannini, Ele;Ferrieres, Jean;Forouhi, Nita G.;Forrester, Terrence;Franco, Oscar H.;Gansevoort, Ron T.;Gieger, Christian;Gudnason, Vilmundur;Haiman, Christopher A.;Harris, Tamara B.;Hattersley, Andrew T.;Heliovaara, Markku;Hicks, Andrew A.;Hingorani, Aroon D.;Hoffmann, Wolfgang;Hofman, Albert;Homuth, Georg;Humphries, Steve E.;Hyppoenen, Elina;Illig, Thomas;Jarvelin, Marjo-Riitta;Johansen, Berit;Jousilahti, Pekka;Jula, Antti M.;Kaprio, Jaakko;Kee, Frank;Keinanen-Kiukaanniemi, Sirkka M.;Kooner, Jaspal S.;Kooperberg, Charles;Kovacs, Peter;Kraja, Aldi T.;Kumari, Meena;Kuulasmaa, Kari;Kuusisto, Johanna;Lakka, Timo A.;Langenberg, Claudia;Le Marchand, Loic;Lehtimaki, Terho;Lyssenko, Valeriya;Mannisto, Satu;Marette, Andre;Matise, Tara C.;McKenzie, Colin A.;McKnight, Barbara;Musk, Arthur W.;Mohlenkamp, Stefan;Morris, Andrew D.;Nelis, Mari;Ohlsson, Claes;Oldehinkel, Albertine J.;Ong, Ken K.;Palmer, Lyle J.;Penninx, Brenda W.;Peters, Annette;Pramstaller, Peter P.;Raitakari, Olli T.;Rankinen, Tuomo;Rao, D. C.;Rice, Treva K.;Ridker, Paul M.;Ritchie, Marylyn D.;Rudan, Igor;Salomaa, Veikko;Samani, Nilesh J.;Saramies, Jouko;Sarzynski, Mark A.;Schwarz, Peter E. H.;Shuldiner, Alan R.;Staessen, Jan A.;Steinthorsdottir, Valgerdur;Stolk, Ronald P.;Strauch, Konstantin;Toenjes, Anke;Tremblay, Angelo;Tremoli, Elena;Vohl, Marie-Claude;Voelker, Uwe;Vollenweider, Peter;Wilson, James F.;Witteman, Jacqueline C.;Adair, Linda S.;Bochud, Murielle;Boehm, Bernhard O.;Bornstein, Stefan R.;Bouchard, Claude;Cauchi, Stephane;Caulfield, Mark J.;Chambers, John C.;Chasman, Daniel I.;Cooper, Richard S.;Dedoussis, George;Ferrucci, Luigi;Froguel, Philippe;Grabe, Hans-Joergen;Hamsten, Anders;Hui, Jennie;Hveem, Kristian;Joeckel, Karl-Heinz;Kivimaki, Mika;Kuh, Diana;Laakso, Markku;Liu, Yongmei;Maerz, Winfried;Munroe, Patricia B.;Njolstad, Inger;Oostra, Ben A.;Palmer, Colin N. A.;Pedersen, Nancy L.;Perola, Markus;Perusse, Louis;Peters, Ulrike;Power, Chris;Quertermous, Thomas;Rauramaa, Rainer;Rivadeneira, Fernando;Saaristo, Timo E.;Saleheen, Danish;Sinisalo, Juha;Slagboom, P. Eline;Snieder, Harold;Spector, Tim D.;Thorsteinsdottir, Unnur R.;Stumvoll, Michael;Tuomilehto, Jaakko;Uitterlinden, Andre G.;Uusitupa, Math;van der Harst, Pim;Veronesi, Giovanni;Walker, Mark;Wareham, Nicholas J.;Watkins, Hugh;Wichmann, H-Erich;Abecasis, Goncalo R.;Assimes, Themistocles L.;Berndt, Sonja I.;Boehnkes, Michael;Borecki, Ingrid B.;Deloukas, Panos;Franke, Lude;Frayling, Timothy M.;Groop, Leif C.;Hunter, David J.;Kaplan, Robert C.;O'Connell, Jeffrey R.;Qi, Lu;Schlessinger, David;Strachan, David P.;Stefansson, Kari;van Dujin, Cornelia M.;Willer, Cristen J.;Visscher, Peter M.;Yang, Jian;Hirschhorn, Joel N.;Zillikens, M. Carola;McCarthy, Mark I.;Speliotes, Elizabeth K.;North, Kari E.;Fox, Caroline S.;Barroso, Ines;Franks, Paul W.;Ingelsson, Erik;Heid, Iris M.;Loos, Ruth J. F.;Cupples, L. Adrienne;Morris, Andrew P.;Lindgren, Cecilia M.;Mohlke, Karen L.
通讯作者：
Mohlke, Karen L.
影响因子：
64.8
作者：
Ehret, Georg B.;Munroe, Patricia B.;Rice, Kenneth M.;Bochud, Murielle;Johnson, Andrew D.;Chasman, Daniel I.;Smith, Albert V.;Tobin, Martin D.;Verwoert, Germaine C.;Hwang, Shih-Jen;Pihur, Vasyl;Vollenweider, Peter;O'Reilly, Paul F.;Amin, Najaf;Bragg-Gresham, Jennifer L.;Teumer, Alexander;Glazer, Nicole L.;Launer, Lenore;Zhao, Jing Hua;Aulchenko, Yurii;Heath, Simon;Sober, Siim;Parsa, Afshin;Luan, Jian'an;Arora, Pankaj;Dehghan, Abbas;Zhang, Feng;Lucas, Gavin;Hicks, Andrew A.;Jackson, Anne U.;Peden, John F.;Tanaka, Toshiko;Wild, Sarah H.;Rudan, Igor;Igl, Wilmar;Milaneschi, Yuri;Parker, Alex N.;Fava, Cristiano;Chambers, John C.;Fox, Ervin R.;Kumari, Meena;Go, Min Jin;van der Harst, Pim;Kao, Wen Hong Linda;Sjogren, Marketa;Vinay, D. G.;Alexander, Myriam;Tabara, Yasuharu;Shaw-Hawkins, Sue;Whincup, Peter H.;Liu, Yongmei;Shi, Gang;Kuusisto, Johanna;Tayo, Bamidele;Seielstad, Mark;Sim, Xueling;Khanh-Dung Hoang Nguyen;Lehtimaki, Terho;Matullo, Giuseppe;Wu, Ying;Gaunt, Tom R.;Onland-Moret, N. Charlotte;Cooper, Matthew N.;Platou, Carl G. P.;Org, Elin;Hardy, Rebecca;Dahgam, Santosh;Palmen, Jutta;Vitart, Veronique;Braund, Peter S.;Kuznetsova, Tatiana;Uiterwaal, Cuno S. P. M.;Adeyemo, Adebowale;Palmas, Walter;Campbell, Harry;Ludwig, Barbara;Tomaszewski, Maciej;Tzoulaki, Ioanna;Palmer, Nicholette D.;Aspelund, Thor;Garcia, Melissa;Chang, Yen-Pei C.;O'Connell, Jeffrey R.;Steinle, Nanette I.;Grobbee, Diederick E.;Arking, Dan E.;Kardia, Sharon L.;Morrison, Alanna C.;Hernandez, Dena;Najjar, Samer;McArdle, Wendy L.;Hadley, David;Brown, Morris J.;Connell, John M.;Hingorani, Aroon D.;Day, Ian N. M.;Lawlor, Debbie A.;Beilby, John P.;Lawrence, Robert W.;Clarke, Robert;Hopewell, Jemma C.;Ongen, Halit;Dreisbach, Albert W.;Li, Yali;Young, J. Hunter;Bis, Joshua C.;Kahonen, Mika;Viikari, Jorma;Adair, Linda S.;Lee, Nanette R.;Chen, Ming-Huei;Olden, Matthias;Pattaro, Cristian;Bolton, Judith A. Hoffman;Koettgen, Anna;Bergmann, Sven;Mooser, Vincent;Chaturvedi, Nish;Frayling, Timothy M.;Islam, Muhammad;Jafar, Tazeen H.;Erdmann, Jeanette;Kulkarni, Smita R.;Bornstein, Stefan R.;Graessler, Juergen;Groop, Leif;Voight, Benjamin F.;Kettunen, Johannes;Howard, Philip;Taylor, Andrew;Guarrera, Simonetta;Ricceri, Fulvio;Emilsson, Valur;Plump, Andrew;Barroso, Ine S.;Khaw, Kay-Tee;Weder, Alan B.;Hunt, Steven C.;Sun, Yan V.;Bergman, Richard N.;Collins, Francis S.;Bonnycastle, Lori L.;Scott, Laura J.;Stringham, Heather M.;Peltonen, Leena;Perola, Markus;Vartiainen, Erkki;Brand, Stefan-Martin;Staessen, Jan A.;Wang, Thomas J.;Burton, Paul R.;Artigas, Maria Soler;Dong, Yanbin;Snieder, Harold;Wang, Xiaoling;Zhu, Haidong;Lohman, Kurt K.;Rudock, Megan E.;Heckbert, Susan R.;Smith, Nicholas L.;Wiggins, Kerri L.;Doumatey, Ayo;Shriner, Daniel;Veldre, Gudrun;Viigimaa, Margus;Kinra, Sanjay;Prabhakaran, Dorairaj;Tripathy, Vikal;Langefeld, Carl D.;Rosengren, Annika;Thelle, Dag S.;Corsi, Anna Maria;Singleton, Andrew;Forrester, Terrence;Hilton, Gina;McKenzie, Colin A.;Salako, Tunde;Iwai, Naoharu;Kita, Yoshikuni;Ogihara, Toshio;Ohkubo, Takayoshi;Okamura, Tomonori;Ueshima, Hirotsugu;Umemura, Satoshi;Eyheramendy, Susana;Meitinger, Thomas;Wichmann, H. -Erich;Cho, Yoon Shin;Kim, Hyung-Lae;Lee, Jong-Young;Scott, James;Sehmi, Joban S.;Zhang, Weihua;Hedblad, Bo;Nilsson, Peter;Smith, George Davey;Wong, Andrew;Narisu, Narisu;Stancakova, Alena;Raffel, Leslie J.;Yao, Jie;Kathiresan, Sekar;O'Donnell, Christopher J.;Schwartz, Stephen M.;Ikram, M. Arfan;Longstreth, W. T., Jr.;Mosley, Thomas H.;Seshadri, Sudha;Shrine, Nick R. G.;Wain, Louise V.;Morken, Mario A.;Swift, Amy J.;Laitinen, Jaana;Prokopenko, Inga;Zitting, Paavo;Cooper, Jackie A.;Humphries, Steve E.;Danesh, John;Rasheed, Asif;Goel, Anuj;Hamsten, Anders;Watkins, Hugh;Bakker, Stephan J. L.;van Gilst, Wiek H.;Janipalli, Charles S.;Mani, K. Radha;Yajnik, Chittaranjan S.;Hofman, Albert;Mattace-Raso, Francesco U. S.;Oostra, Ben A.;Demirkan, Ayse;Isaacs, Aaron;Rivadeneira, Fernando;Lakatta, Edward G.;Orru, Marco;Scuteri, Angelo;Ala-Korpela, Mika;Kangas, Antti J.;Lyytikainen, Leo-Pekka;Soininen, Pasi;Tukiainen, Taru;Wurtz, Peter;Ong, Rick Twee-Hee;Doerr, Marcus;Kroemer, Heyo K.;Voelker, Uwe;Voelzke, Henry;Galan, Pilar;Hercberg, Serge;Lathrop, Mark;Zelenika, Diana;Deloukas, Panos;Mangino, Massimo;Spector, Tim D.;Zhai, Guangju;Meschia, James F.;Nalls, Michael A.;Sharma, Pankaj;Terzic, Janos;Kumar, M. V. Kranthi;Denniff, Matthew;Zukowska-Szczechowska, Ewa;Wagenknecht, Lynne E.;Fowkes, F. Gerald R.;Charchar, Fadi J.;Schwarz, Peter E. H.;Hayward, Caroline;Guo, Xiuqing;Rotimi, Charles;Bots, Michiel L.;Brand, Eva;Samani, Nilesh J.;Polasek, Ozren;Talmud, Philippa J.;Nyberg, Fredrik;Kuh, Diana;Laan, Maris;Hveem, Kristian;Palmer, Lyle J.;van der Schouw, Yvonne T.;Casas, Juan P.;Mohlke, Karen L.;Vineis, Paolo;Raitakari, Olli;Ganesh, Santhi K.;Wong, Tien Y.;Tai, E. Shyong;Cooper, Richard S.;Laakso, Markku;Rao, Dabeeru C.;Harris, Tamara B.;Morris, Richard W.;Dominiczak, Anna F.;Kivimaki, Mika;Marmot, Michael G.;Miki, Tetsuro;Saleheen, Danish;Chandak, Giriraj R.;Coresh, Josef;Navis, Gerjan;Salomaa, Veikko;Han, Bok-Ghee;Zhu, Xiaofeng;Kooner, Jaspal S.;Melander, Olle;Ridker, Paul M.;Bandinelli, Stefania;Gyllensten, Ulf B.;Wright, Alan F.;Wilson, James F.;Ferrucci, Luigi;Farrall, Martin;Tuomilehto, Jaakko;Pramstaller, Peter P.;Elosua, Roberto;Soranzo, Nicole;Sijbrands, Eric J. G.;Altshuler, David;Loos, Ruth J. F.;Shuldiner, Alan R.;Gieger, Christian;Meneton, Pierre;Uitterlinden, Andre G.;Wareham, Nicholas J.;Gudnason, Vilmundur;Rotter, Jerome I.;Rettig, Rainer;Uda, Manuela;Strachan, David P.;Witteman, Jacqueline C. M.;Hartikainen, Anna-Liisa;Beckmann, Jacques S.;Boerwinkle, Eric;Vasan, Ramachandran S.;Boehnke, Michael;Larson, Martin G.;Jarvelin, Marjo-Riitta;Psaty, Bruce M.;Abecasis, Goncalo R.;Chakravarti, Aravinda;Elliott, Paul;van Duijn, Cornelia M.;Newton-Cheh, Christopher;Levy, Daniel;Caulfield, Mark J.;Johnson, Toby
通讯作者：
Johnson, Toby
影响因子：
9.8
作者：
Ganesh, Santhi K.;Chasman, Daniel I.;Chakravarti, Aravinda
通讯作者：
Chakravarti, Aravinda
DOI：
10.1126/science.1222794
发表时间：
2012-09-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Maurano MT;Humbert R;Rynes E;Thurman RE;Haugen E;Wang H;Reynolds AP;Sandstrom R;Qu H;Brody J;Shafer A;Neri F;Lee K;Kutyavin T;Stehling-Sun S;Johnson AK;Canfield TK;Giste E;Diegel M;Bates D;Hansen RS;Neph S;Sabo PJ;Heimfeld S;Raubitschek A;Ziegler S;Cotsapas C;Sotoodehnia N;Glass I;Sunyaev SR;Kaul R;Stamatoyannopoulos JA
通讯作者：
Stamatoyannopoulos JA