Facile Preparation of Gold-Decorated Fe3O4 Nanoparticles for CT and MR Dual-Modal Imaging
Facile Preparation of Gold-Decorated Fe3O4 Nanoparticles for CT and MR Dual-Modal Imaging
复制标题
轻松制备用于 CT 和 MR 双模态成像的金修饰 Fe3O4 纳米颗粒
DOI：
10.3390/ijms19124049
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发表时间：
2018-12-01
影响因子：
5.6
通讯作者：
Fan, Hai Ming
中科院分区：
文献类型：
--
作者：
Cai, Jing;Miao, Yu Qing;Fan, Hai Ming
能够进行非侵入性多模态成像的多功能纳米探针的开发对于精确的肿瘤诊断至关重要。在此，我们报告了一种简便的聚合物辅助的方法来生产Au-Fe 3 O 4纳米复合材料（NCPs）的双模磁共振（MR）和X射线计算机断层扫描（CT）成像的肿瘤。在这种方法中，氨基官能化的Au纳米球首先通过双官能聚合物SH-PEG-NH 2的表面改性获得。在我们以前的工作中，亲水性和羧基功能化的Fe 3 O 4纳米粒子的反胶束氧化相转移制备。通过酰胺化反应将Au纳米粒子与亲水性Fe 3 O 4纳米粒子偶联。所获得的Au-Fe 3 O 4纳米复合物在Au浓度为8 mg/mL时显示出高的r2相关性（157.92 mM-1 s-1）和Hounsfield单位（HU）值（270 HU），并且可以用作异种移植肿瘤模型的双模态MR/CT成像的纳米探针。我们的工作提供了一种简便的方法来制备用于双模态MR/CT成像的Au-Fe_3 O_4纳米复合材料，该方法可以扩展到制备用于多模态生物成像的其他多功能纳米颗粒。
The development of a multifunctional nanoprobe capable of non-invasive multimodal imaging is crucial for precise tumour diagnosis. Herein, we report a facile polymer-assisted method to produce Au-Fe3O4 nanocomposites (NCPs) for the dual-modal magnetic resonance (MR) and X-ray computed tomography (CT) imaging of tumours. In this approach, amino-functionalized Au nanospheres were first obtained by surface modification of the bifunctional polymer SH-PEG-NH2. Hydrophilic and carboxyl-functionalized Fe3O4 nanoparticles were produced by phase transfer of reverse micelle oxidation in our previous work. The Au nanoparticles were conjugated with hydrophilic Fe3O4 nanoparticles through an amide reaction. The obtained Au-Fe3O4 nanocomposites display a high r2 relativity (157.92 mM−1 s−1) and a Hounsfield units (HU) value (270 HU) at Au concentration of 8 mg/mL and could be applied as nanoprobes for the dual-modal MR/CT imaging of a xenografted tumour model. Our work provides a facile method to prepare Au-Fe3O4 nanocomposites for dual-modal MR/CT imaging, and this method can be extended to prepare other multifunctional nanoparticles for multimodal bioimaging.