PRIMARY STRUCTURE OF PORCINE RELAXIN - HOMOLOGY WITH INSULIN AND RELATED GROWTH-FACTORS
PRIMARY STRUCTURE OF PORCINE RELAXIN - HOMOLOGY WITH INSULIN AND RELATED GROWTH-FACTORS
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DOI：
10.1038/267544a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
BRYANTGREENWOOD, G
中科院分区：
文献类型：
--
作者：
JAMES, R;NIALL, H;BRYANTGREENWOOD, G
HISAW和同事们首先描述了一种来自母猪黄体的因子，该因子在雌激素刺激的豚鼠中引起耻骨联合松弛。随后的研究表明，这种被称为松弛素的活性物质是一种低分子量的肽激素。在母猪、豚鼠、兔子、小鼠和大鼠怀孕期间，以及最近在人类怀孕期间，都证实了这种病毒的存在。它的作用包括扩张和软化子宫颈，抑制子宫收缩和放松耻骨联合和其他盆腔关节。松弛素的分子量约为6000，由两条由二硫化物桥连接的不相同的链组成。我们现在已经确定了猪松弛素的完整氨基酸序列，并在此报告。
HISAW and co-workers1,2first described a factor from sow corpora lutea that caused relaxation of the pubic symphysis in oestrogen-primed guinea pigs. Subsequent studies have shown that the active substance, termed relaxin, is a low molecular weight peptide hormone. Its presence has been demonstrated during pregnancy in female pigs, guinea pigs, rabbits, mice and rats3,4, and, more recently, in humans5. Its actions include dilatation and softening of the cervix, inhibition of uterine contractions and relaxation of the pubic symphysis and other pelvic joints. Relaxin, which has a molecular weight of approximately 6,000, consists of two non-identical chains joined by disulphide bridges6. We have now determined, and report here, the complete amino acid sequence of porcine relaxin.