Cell surface F1Fo ATP synthase:: A new paradigm?
Cell surface F1Fo ATP synthase:: A new paradigm?
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DOI：
10.1080/07853890600928698
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发表时间：
2006-01-01
影响因子：
4.4
通讯作者：
Pizzo, Salvatore V.
中科院分区：
文献类型：
--
作者：
Chi, Sulene L.;Pizzo, Salvatore V.
线粒体F1F0三磷酸腺苷(ATP)合成酶是已知的研究最深入的酶复合体之一。然而，一些新的观察表明，该酶也位于细胞表面，需要进一步研究。虽然线粒体合酶利用氧化磷酸化产生的质子梯度来为ATP合成提供动力，但细胞表面合酶却参与了许多活动，包括调节细胞内pH、细胞对抗血管生成药物的反应和胆固醇的稳态。有趣的是，将这些不同的细胞表面ATP合成酶功能模型联系在一起的一个共同线索是这种酶的明显空洞分布。最近关于细胞表面三磷酸腺苷合成酶的研究表明，它在调节血清胆固醇水平、细胞增殖和抗肿瘤策略方面有着广泛的应用。本文综述了细胞表面三磷酸腺苷合成酶的表达、相互作用、功能和抑制的后果，该酶目前显示出范式和位置的转变。
The mitochondrial F1F0 adenosine triphosphate (ATP) synthase is one of the most thoroughly studied enzyme complexes known. Yet, a number of new observations suggesting that the enzyme is also located on the cell surface necessitate further investigation. While the mitochondrial synthase utilizes the proton gradient generated by oxidative phosphorylation to power ATP synthesis, the cell surface synthase has instead been implicated in numerous activities, including the mediation of intracellular pH, cellular response to antiangiogenic agents, and cholesterol homeostasis. Intriguingly, a common thread uniting these various models of cell surface ATP synthase functions is the apparently caveolar distribution of the enzyme. Recent studies concerning the cell surface ATP synthase manifest applications in the regulation of serum cholesterol levels, cellular proliferation and antitumor strategies. This review addresses the expression, interactions, functions, and consequences of inhibition of cell surface ATP synthase, an enzyme now displaying a shift in paradigm, as well as of location.