Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury
Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury
复制标题
DOI：
10.1016/j.brainres.2014.10.048
复制
发表时间：
2015-09-04
期刊：
影响因子：
2.9
通讯作者：
Ferguson, Adam R.
中科院分区：
文献类型：
--
作者：
Nielson, Jessica L.;Haefeli, Jenny;Ferguson, Adam R.
最近的临床前进展突出了旨在促进脊髓损伤（SCI）损伤的脊髓回路再生和可塑性的治疗潜力。随着几个有前途的候选人被考虑转化为临床试验，SCI社区呼吁非人类灵长类动物模型作为关键的验证步骤，以测试这些疗法的疗效和有效性，然后再进行人体测试。本文回顾了加州脊髓联盟（CSCC），一个多学科的专家团队，来自5个大学的加州医学和研究中心，开发这一关键的翻译SCI模型之前和正在进行的努力。我们专注于CSCC收集的越来越多的高分辨率数据，以及我们努力开发一个生物医学信息学框架，旨在利用多维数据来监测手和手臂功能的可塑性和修复目标恢复。虽然许多研究人员的主要重点是恢复自主运动控制，我们也描述了我们正在进行的努力，以增加感觉功能的评估，包括疼痛，手术期间的生命体征，膀胱和肠功能的恢复。通过汇集我们的多维数据资源并为SCI的临床相关转化模型建立统一的数据库基础设施，我们现在处于一个独特的位置，可以测试有前途的治疗策略对SCI整个综合征的疗效。我们回顾分析强调运动，感觉，自主神经和病理之间的交叉贡献的整体功能恢复。这篇文章是题为SI：脊髓损伤的特刊的一部分。(C)2014爱思唯尔有限公司版权所有。
Recent preclinical advances highlight the therapeutic potential of treatments aimed at boosting regeneration and plasticity of spinal circuitry damaged by spinal cord injury (SCI). With several promising candidates being considered for translation into clinical trials, the SCI community has called for a non-human primate model as a crucial validation step to test efficacy and validity of these therapies prior to human testing. The present paper reviews the previous and ongoing efforts of the California Spinal Cord Consortium (CSCC), a multi-disciplinary team of experts from 5 University of California medical and research centers, to develop this crucial translational SCI model. We focus on the growing volumes of high resolution data collected by the CSCC, and our efforts to develop a biomedical informatics framework aimed at leveraging multidimensional data to monitor plasticity and repair targeting recovery of hand and arm function. Although the main focus of many researchers is the restoration of voluntary motor control, we also describe our ongoing efforts to add assessments of sensory function, including pain, vital signs during surgery, and recovery of bladder and bowel function. By pooling our multidimensional data resources and building a unified database infrastructure for this clinically relevant translational model of SCI, we are now in a unique position to test promising therapeutic strategies' efficacy on the entire syndrome of SCI. We review analyses highlighting the intersection between motor, sensory, autonomic and pathological contributions to the overall restoration of function. This article is part of a Special Issue entitled SI: Spinal cord injury. (C) 2014 Elsevier B.V. All rights reserved.