Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages.
Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages.
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DOI：
10.1080/22221751.2021.1925160
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发表时间：
2021-12
影响因子：
13.2
通讯作者：
He P
中科院分区：
文献类型：
--
作者：
Wang Y;Fan X;Du L;Liu B;Xiao H;Zhang Y;Wu Y;Liu F;Chang YF;Guo X;He P
钩端螺旋体病是由致病性钩端螺旋体引起的一种人畜共患疾病。巨噬细胞通过吞噬作用和细胞因子产生介导病原体的消除。清道夫受体A1（SR-A1）是介导这一过程的关键受体之一，在天然免疫中起着复杂的作用。然而，SR-A1在抵抗致病性钩端螺旋体入侵的免疫应答中的作用尚不清楚。在本研究中，我们发现SR-A1是一个重要的非调理吞噬受体对钩端螺旋体的小鼠巨噬细胞。然而，WT小鼠腹腔注射钩端螺旋体比SR-A1-/-小鼠表现出更明显的黄疸、皮下肿胀以及血液和组织中更高的细菌负荷。在WT小鼠中也观察到细胞因子和炎症介质水平加重，肝脏中招募的巨噬细胞高于SR-A1-/-小鼠。我们的研究结果共同揭示，虽然有益于由巨噬细胞的钩端螺旋体的摄取，SR-A1可能被钩端螺旋体利用来调节炎症激活和增加宿主感染的易感性。这些结果为我们了解L.质问者
Leptospirosis, caused by pathogenic Leptospira species, has emerged as a widespread zoonotic disease worldwide. Macrophages mediate the elimination of pathogens through phagocytosis and cytokine production. Scavenger receptor A1 (SR-A1), one of the critical receptors mediating this process, plays a complicated role in innate immunity. However, the role of SR-A1 in the immune response against pathogenic Leptospira invasion is unknown. In the present study, we found that SR-A1 is an important nonopsonic phagocytic receptor on murine macrophages for Leptospira. However, intraperitoneal injection of leptospires into WT mice presented with more apparent jaundice, subcutaneous hemorrhaging, and higher bacteria burdens in blood and tissues than that of SR-A1-/- mice. Exacerbated cytokine and inflammatory mediator levels were also observed in WT mice and higher recruited macrophages in the liver than those of SR-A1-/- mice. Our findings collectively reveal that although beneficial in the uptake of Leptospira by macrophage, SR-A1 might be exploited by Leptospira to modulate inflammatory activation and increase the susceptibility of infection in the host. These results provide our new insights into the innate immune response during early infection by L. interrogans.
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影响因子：
6
作者：
Ishiguro, T;Naito, M;Kodama, T
通讯作者：
Kodama, T
影响因子：
5.5
作者：
Cholewa, Jill;Nikolic, Dejan;Post, Steven R.
通讯作者：
Post, Steven R.
DOI：
10.1073/pnas.88.11.4931
发表时间：
1991-06-01
影响因子：
11.1
作者：
FREEMAN, M;EKKEL, Y;KRIEGER, M
通讯作者：
KRIEGER, M
影响因子：
5.7
作者：
Ferrer MF;Scharrig E;Charo N;Rípodas AL;Drut R;Carrera Silva EA;Nagel A;Nally JE;Montes de Oca DP;Schattner M;Gómez RM
通讯作者：
Gómez RM
DOI：
10.1165/rcmb.2006-0128oc
发表时间：
2006-10-01
影响因子：
6.4
作者：
Arredouani, Mohamed S.;Yang, Zhiping;Kobzik, Lester
通讯作者：
Kobzik, Lester