The longitudinal relationship between cannabis use and hypertension
The longitudinal relationship between cannabis use and hypertension
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DOI：
10.1111/dar.13266
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发表时间：
2021-02-28
影响因子：
3.8
通讯作者：
Imtiaz, Sameer
中科院分区：
文献类型：
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作者：
Haleem, Ahmed;Hwang, Yoseob Joseph;Imtiaz, Sameer
导言根据先前的流行病学研究，大麻使用和高血压之间的关系尚不清楚。因此，我们利用来自美国的大量基于人群的样本，在3年的时间里检验了这种关系。方法从国家酒精及相关疾病流行病学调查第一波(2001/2002)和第二波(2004/2005)获得自我报告的纵向数据。样本仅限于那些在基线时没有报告高血压的参与者(n=26844；51%40岁及以上，51%女性，71%白人)。使用X(2)检验来检验按高血压发病率分层的混杂因素的分布。然后，在调整混杂因素的情况下，对终生吸食大麻、12个月吸食大麻和12个月吸食大麻的频率与高血压发病率之间的关系进行多元Logistic回归分析。然而，这些关系因年龄而变得混乱。调整混杂因素后，终生吸食大麻(优势比，95%可信区间0.89，0.77~1.02)、12个月吸食大麻次数(0.78，0.56~1.09)和12个月吸食大麻频率[至少每月吸食大麻(0.85，0.57~1.28)和少于每月吸食大麻次数(0.67，0.40~1.11)]与高血压的发生无关联。
Introduction The relationship between cannabis use and hypertension is not clear based on prior epidemiological studies. Thus, we examined this relationship over a 3-year follow-up period using a large population-based sample from the USA.Methods Self-reported longitudinal data were obtained from the National Epidemiologic Survey on Alcohol and Related Conditions Wave 1 (2001/2002) and Wave 2 (2004/2005). The sample was restricted to participants who did not report hypertension at baseline (n = 26 844; 51% 40 years and older, 51% female, 71% white). chi(2)-tests were used to examine the distributions of confounders stratified by the incidence of hypertension. Thereafter, multiple logistic regression analyses were conducted to quantify the relationships between lifetime cannabis use, 12-month cannabis use and 12-month cannabis use frequency and incidence of hypertension while adjusting for confounders.Results Cannabis use was associated with a decreased incidence of hypertension in the unadjusted analyses. However, the relationships were confounded by age. After adjustment for all confounders, neither lifetime cannabis use (odds ratio, 95% confidence interval 0.89, 0.77 to 1.02), 12-month cannabis use (0.78, 0.56 to 1.09) nor 12-month cannabis use frequency [at least monthly use (0.85, 0.57 to 1.28) and less than monthly use (0.67, 0.40 to 1.11)] were associated above chance with the incidence of hypertension.Discussion and Conclusions Lifetime cannabis use, 12-month cannabis use and 12-month cannabis use frequency were not associated with the incidence of hypertension.