A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates
A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates
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DOI：
10.15252/msb.20145537
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发表时间：
2015-04-01
影响因子：
9.9
通讯作者：
Hwa, Terence
中科院分区：
文献类型：
--
作者：
Hermsen, Rutger;Okano, Hiroyuki;Hwa, Terence
当细菌在含有多个碳底物的培养基中培养时，它们经常同时消耗这些底物。在了解大肠杆菌细胞通过cAMP-CRP信号表现出的代谢协调方面的最新进展的基础上，我们证明了当底物被共同利用时，这个信号系统对总的碳吸收通量做出反应，并推导出一个数学公式，该公式仅基于单个底物上的生长速度来准确预测所产生的生长速度。
When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by Escherichia coli cells through cAMP-Crp signaling, we show that this signaling system responds to the total carbon-uptake flux when substrates are co-utilized and derive a mathematical formula that accurately predicts the resulting growth rate, based only on the growth rates on individual substrates.