Suppression of conditioned odor approach by feeding is independent of taste and nutritional value in Drosophila.
Suppression of conditioned odor approach by feeding is independent of taste and nutritional value in Drosophila.
复制标题
通过喂食抑制条件气味的方法与果蝇的味道和营养价值无关。
DOI：
10.1016/j.cub.2013.03.059
复制
发表时间：
2013
期刊：
影响因子：
9.2
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Gruber;F.;Knapek;S.;Fujita;M.;Matsuo;K.;Shinzato;N.;Bräcker;L.;Siwanowicz;I.;Tanimura;T. and Tanimoto;H.
动机控制行为[1]。各种与食物相关的行为经历饥饿，饱腹感和其他状态的动机调节[2-4]。在这里，我们寻找关键的饱食因素调节方法的气味与糖奖励在果蝇。我们选择性地操纵与进食相关的不同参数，如内部葡萄糖水平，并确定抑制条件性气味方法所需的参数。令人惊讶的是，血淋巴中的葡萄糖水平，营养价值，食物的甜度和摄入量（高于最小阈值）并不影响行为抑制。相反，我们发现摄入食物的总渗透压是一个关键的饱足因素。与此同时，我们发现，通过人工刺激表达脂肪运动激素（AKH）的心体细胞，可暂时抑制条件性方法，这会导致血淋巴碳水化合物和脂质浓度升高[5，6]。这一结果意味着，血淋巴渗透压的上升，没有喂养的经验，是足以满足条件气味的方法。AKH刺激并不影响先天糖偏好，这表明多种饱足信号控制不同的食欲行为。
Motivation controls behavior [1]. A variety of food-related behaviors undergo motivational modulation by hunger, satiety, and other states [2–4]. Here we searched for critical satiation factors modulating approach to an odor associated with sugar reward inDrosophila melanogaster. We selectively manipulated different parameters associated with feeding, such as internal glucose levels, and determined which are required for suppressing conditioned odor approach. Surprisingly, glucose levels in the hemolymph, nutritional value, sweetness of the food, and ingested volume (above a minimal threshold) did not influence behavior suppression. Instead, we found that the total osmolarity of ingested food is a critical satiation factor. In parallel, we found that conditioned approach is transiently suppressed by artificial stimulation of adipokinetic hormone (AKH) expressing corpora cardiaca cells, which causes elevation of hemolymph carbohydrate and lipid concentrations [5, 6]. This result implies that a rise in hemolymph osmolarity, without the experience of feeding, is sufficient to satiate conditioned odor approach. AKH stimulation did not affect innate sugar preference, suggesting that multiple satiation signals control different sets of appetitive behaviors.