Disruption of a neuropeptide gene, flp-1, causes multiple behavioral defects in Caenorhabditis elegans
Disruption of a neuropeptide gene, flp-1, causes multiple behavioral defects in Caenorhabditis elegans
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DOI：
10.1126/science.281.5383.1686
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发表时间：
1998-09-11
期刊：
影响因子：
56.9
通讯作者：
Li, C
中科院分区：
文献类型：
--
作者：
Nelson, LS;Rosoff, ML;Li, C
神经肽是神经系统中重要的信号分子。秀丽隐杆线虫FMRFamide（Phe-Met-Arg-Phe-amide）相关神经肽基因家族由至少18个基因组成，可编码53种不同的FMRFamide相关肽。这些基因之一flp-1的破坏会导致许多行为缺陷，包括不协调、多动和对高渗透压不敏感。相反，flp-1的过度表达导致相反的表型。上位性分析的基础上，flp-1基因产物出现的信号上游的G蛋白偶联的第二信使系统。这些结果表明，不同水平的FLP-1神经肽可以深刻地影响行为，这个大的神经肽基因家族的成员在C。优雅的。
Neuropeptides serve as important signaling molecules in the nervous system. The FMRFamide (Phe-Met-Arg-Phe-amide)-related neuropeptide gene family in the nematode Caenorhabditis elegans is composed of at Least 18 genes that may encode 53 distinct FMRFamide-related peptides. Disruption of one of these genes, flp-1, causes numerous behavioral defects, including uncoordination, hyperactivity, and insensitivity to high osmolarity. Conversely, overexpression of flp-1 results in the reciprocal phenotypes. On the basis of epistasis analysis, flp-1 gene products appear to signal upstream of a G protein-coupled second messenger system. These results demonstrate that varying the levels of FLP-1 neuropeptides can profoundly affect behavior and that members of this large neuropeptide gene family are not functionally redundant in C. elegans.