Methyl-CpG binding domain 4 tagging polymorphisms and esophageal cancer risk in a Chinese population.
Methyl-CpG binding domain 4 tagging polymorphisms and esophageal cancer risk in a Chinese population.
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甲基-CpG结合域4标记多态性与中国人群食管癌风险
DOI：
10.1097/cej.0000000000000081
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发表时间：
2015
影响因子：
2.4
通讯作者：
Zheng Liang
中科院分区：
文献类型：
--
作者：
Yin Jun;Shi Yijun;Zuo Junbo;Tang Weifeng;Wang Liming;Wang Xu;Shao Aizhong;Ding Guowen;Liu Chao;Liu Ruiping;Chen Suocheng;Gu Haiyong;Zheng Liang
2009年，食道癌在中国最常见的诊断癌症中排名第五，在癌症相关死亡中排名第四。食管鳞癌(ESCC)占食道癌的90%以上。遗传因素可能在食管鳞癌的发生发展中起重要作用。我们进行了一项以医院为基础的病例对照研究，以评估甲基-CpG结合结构域4(MBD4)rs3138373A>；G、rs2005618T>；C和rs3138355 G>；A标签单核苷酸多态与食管鳞癌发病风险的关系。共招募了629名ESCC患者和686名对照。采用连接检测反应法进行基因分型。以MBD4 rs3138355GG纯合子为参照组，GA、AA和GA/AA三种基因型与食管鳞癌的发病风险无关。在隐性模型中，以MBD4rs3138355GG/GA基因型为参照组，AA纯合子与食管癌发病风险降低28%相关(AA与GG/GA：调整优势比=0.72，95%可信区间=0.53~0.99，P=0.040)。MBD4基因rs3138373A>；G和rs2005618T>；C单核苷酸多态与食管鳞癌风险无关。在男性和老年患者中，MBD4 rs3138355 G>；A多态与ESCC风险显著降低相关。在男性患者和老年人中，MBD4 rs3138355 GG基因型与ESCC风险降低相关。此外，还需要更大规模的研究来证实这些当前的发现。
In 2009, esophageal cancer was recorded as the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China. Esophageal squamous cell carcinoma (ESCC) accounts for more than 90% of esophageal cancers. Genetic factors might play an important role in the carcinogenesis of ESCC. We conducted a hospital-based case–control study to evaluate the association between methyl-CpG binding domain 4 (MBD4) rs3138373 A> G, rs2005618 T> C, and rs3138355 G> A tag single nucleotide polymorphisms and the risk of developing ESCC. A total of 629 ESCC patients and 686 controls were recruited. Genotypes were determined using the ligation detection reaction method. When the MBD4 rs3138355 GG homozygous genotype was used as the reference group, the GA, AA, and GA/AA genotypes were not associated with ESCC risk. In the recessive model, when the MBD4 rs3138355 GG/GA genotypes were used as the reference group, the AA homozygous genotype was associated with a 28% decreased risk for ESCC (AA vs. GG/GA: adjusted odds ratio= 0.72, 95% confidence interval= 0.53–0.99, P= 0.040). The MBD4 rs3138373 A> G and rs2005618 T> C single nucleotide polymorphisms were not associated with ESCC risk. The MBD4 rs3138355 G> A polymorphism was associated with a significantly decreased risk of ESCC among male and older patients. The MBD4 rs3138355 GG genotype was associated with a decreased risk of ESCC among male patients and the elderly. Additional, larger studies are required to confirm these current findings.