Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery.
Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery.
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DOI：
10.1021/mp900090z
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发表时间：
2009-07
影响因子：
4.9
通讯作者：
Yeo Y
中科院分区：
文献类型：
--
作者：
Gullotti E;Yeo Y
纳米药物的主要目标之一是开发一种能够选择性地将抗癌药物输送到靶向肿瘤的纳米载体。广泛的努力已经导致了几个肿瘤靶向的纳米载体，其中一些已经被批准用于临床。大多数纳米载体通过增强的渗透性和滞留效应实现对肿瘤的选择性聚集。靶向分子，如抗体、多肽、配体或核酸附着在纳米载体上，进一步增强了它们在靶组织中的识别和内化。虽然隐形和靶向功能对于有效和选择性地向肿瘤输送药物都很重要，但同时实现这两个功能往往是困难的。最近的一些目标战略有可能克服这一挑战。这些策略利用肿瘤独特的细胞外环境来改变长循环的纳米载体，以肿瘤特异性的方式释放药物或与细胞相互作用。本文结合实例讨论了利用环境刺激激活纳米载体的新靶向策略。简要讨论了肿瘤靶向纳米载体的传统策略，重点讨论了它们的成就和挑战。
One of the main goals of nanomedicine is to develop a nanocarrier that can selectively deliver anti-cancer drugs to the targeted tumors. Extensive efforts have resulted in several tumor-targeted nanocarriers, some of which are approved for clinical use. Most nanocarriers achieve tumor-selective accumulation through the enhanced permeability and retention effect. Targeting molecules such as antibodies, peptides, ligands, or nucleic acids attached to the nanocarriers further enhance their recognition and internalization by the target tissues. While both the stealth and targeting features are important for effective and selective drug delivery to the tumors, achieving both features simultaneously is often found to be difficult. Some of the recent targeting strategies have the potential to overcome this challenge. These strategies utilize the unique extracellular environment of tumors to change the long-circulating nanocarriers to release the drug or interact with cells in a tumor-specific manner. This review discusses the new targeting strategies with recent examples, which utilize the environmental stimuli to activate the nanocarriers. Traditional strategies for tumor-targeted nanocarriers are briefly discussed with an emphasis on their achievements and challenges.
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影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
影响因子：
6.4
作者：
Chau, Y;Padera, RF;Langer, R
通讯作者：
Langer, R
影响因子：
14
作者：
Cheng, Jianjun;Teply, Benjamin A.;Farokhzad, Omid C.
通讯作者：
Farokhzad, Omid C.
DOI：
10.1073/pnas.0601755103
发表时间：
2006-04-18
影响因子：
11.1
作者：
Farokhzad, OC;Cheng, JJ;Langer, R
通讯作者：
Langer, R
影响因子：
4.7
作者：
Bae, Y;Nishiyama, N;Kataoka, K
通讯作者：
Kataoka, K