Gestational Vitamin 25(OH)D Status as a Risk Factor for Receptive Language Development: A 24-Month, Longitudinal, Observational Study.
Gestational Vitamin 25(OH)D Status as a Risk Factor for Receptive Language Development: A 24-Month, Longitudinal, Observational Study.
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DOI：
10.3390/nu7125499
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发表时间：
2015-12-02
期刊：
影响因子：
5.9
通讯作者：
Ferry RJ Jr
中科院分区：
文献类型：
--
作者：
Tylavsky FA;Kocak M;Murphy LE;Graff JC;Palmer FB;Völgyi E;Diaz-Thomas AM;Ferry RJ Jr
新出现的数据表明，儿童和青少年时期的维生素D水平会影响神经认知发育。本研究的目的是探讨妊娠期25(OH)D状态是否与儿童早期认知和接受性语言发育有关。影响早期儿童神经认知发育和学习的条件研究（CANDLE）纳入了来自田纳西州谢尔比县的1503名健康单胎妊娠中期的母婴。在1020名可获得25(OH)D水平的参与者中，妊娠中期的平均25(OH)D水平为22.3 ng/mL（范围为5.9-68.4），41.7%的值<20 ng/dL。随着妊娠中期25(OH)D水平从<20 ng/dL，到20 - 29.99 ng/dL，再到≥30 ng/dL，认知和语言评分呈阶梯式上升。在控制社会经济地位、种族、烟草制品使用、出生胎龄和2岁时的年龄后，妊娠期25(OH)D与接受性语言发展呈正相关（p < 0.017），但与认知和表达性语言发展无关。
Emerging data suggest that vitamin D status during childhood and adolescence can affect neurocognitive development. The purpose of this study was to investigate whether gestational 25(OH)D status is associated with early childhood cognitive and receptive language development. The Conditions Affecting Neurocognitive Development and Learning in Early Childhood Study (CANDLE) study enrolled 1503 mother-child dyads during the second trimester of healthy singleton pregnancies from Shelby County TN. Among 1020 participants of the total CANDLE cohort for whom 25(OH)D levels were available, mean gestational 25(OH)D level during the second trimester was 22.3 ng/mL (range 5.9–68.4), with 41.7% of values <20 ng/dL. Cognitive and language scaled scores increased in a stair-step manner as gestational 25(OH)D levels in the second trimester rose from <20 ng/dL, through 20–29.99 ng/dL, to ≥30 ng/dL. When controlling for socioeconomic status, race, use of tobacco products, gestational age of the child at birth, and age at the 2-year assessment, the gestational 25(OH)D was positively related to receptive language development (p < 0.017), but not cognitive or expressive language.