Effects of solvent osmolarity and viscosity on cartilage energy dissipation under high-frequency loading
Effects of solvent osmolarity and viscosity on cartilage energy dissipation under high-frequency loading
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DOI：
10.1016/j.jmbbm.2021.105014
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发表时间：
2021-12-03
影响因子：
3.9
通讯作者：
Henak, Corinne R.
中科院分区：
文献类型：
--
作者：
Hwang, Jin Wook;Chawla, Dipul;Henak, Corinne R.
关节软骨是一种空间异质、耗散的生物水凝胶，具有高流体体积分数。虽然能量耗散在延迟软骨损伤的背景下是重要的，但在不同渗透压和粘度的介质中平衡的关节软骨的动态行为并没有被广泛理解。本研究探讨了软骨在不同渗透压和粘度的介质中平衡时的力学行为。在低（1 Hz）和高（75-300 Hz）频率下测量动态模量和相移，将软骨样品压缩至不同的偏移应变水平。增加溶液的渗透压和粘度都独立地导致较大的能量耗散和软骨在低和高频率下的动态模量降低。由不同渗透压引起的机械性能改变可能是由于组织内渗透性和液体体积分数的变化。溶液粘度的影响可能是由于固体-流体界面处的摩擦相互作用，影响能量耗散。这些发现强调了间质液对组织能量耗散能力的重要性，这可以影响软骨损伤的发生。
Articular cartilage is a spatially heterogeneous, dissipative biological hydrogel with a high fluid volume fraction. Although energy dissipation is important in the context of delaying cartilage damage, the dynamic behavior of articular cartilage equilibrated in media of varied osmolarity and viscosity is not widely understood. This study investigated the mechanical behaviors of cartilage when equilibrated to media of varying osmolarity and viscosity. Dynamic moduli and phase shift were measured at both low (1 Hz) and high (75-300 Hz) frequency, with cartilage samples compressed to varied offset strain levels. Increasing solution osmolarity and viscosity both independently resulted in larger energy dissipation and decreased dynamic modulus of cartilage at both low and high frequency. Mechanical property alterations induced by varying osmolarity are likely due to the change in permeability and fluid volume fraction within the tissue. The effects of solution viscosity are likely due to frictional interactions at the solid-fluid interface, affecting energy dissipation. These findings highlight the significance of interstitial fluid on the energy dissipation capabilities of the tissue, which can influence the onset of cartilage damage.