Acute Respiratory Illnesses in Children in the SARS-CoV-2 Pandemic: Prospective Multicenter Study.
Acute Respiratory Illnesses in Children in the SARS-CoV-2 Pandemic: Prospective Multicenter Study.
复制标题
DOI：
10.1542/peds.2021-051462
复制
发表时间：
2021-08
期刊：
影响因子：
8
通讯作者：
Halasa NB
中科院分区：
文献类型：
--
作者：
Haddadin Z;Schuster JE;Spieker AJ;Rahman H;Blozinski A;Stewart L;Campbell AP;Lively JY;Michaels MG;Williams JV;Boom JA;Sahni LC;Staat M;McNeal M;Selvarangan R;Harrison CJ;Weinberg GA;Szilagyi PG;Englund JA;Klein EJ;Curns AT;Rha B;Langley GE;Hall AJ;Patel MM;Halasa NB
针对新冠肺炎的非药物干预可能在减少病毒性急性呼吸道疾病方面发挥作用。这项研究旨在评估新冠肺炎大流行之前和期间儿童呼吸道合胞病毒和流感ARI的频率。这项研究是一项前瞻性、多中心、以人群为基础的ARI监测，包括美国7个城市的18岁儿童在急诊科(ED)和住院环境中出现发烧和/或呼吸道症状。采集呼吸道样本，通过分子检测进行评价。数据按日历周进行分析。使用广义线性混合效应模型评估社区缓解与合格病例数量之间的关联，以及RSV和流感检测阳性的比例。总体而言，45,759名儿童符合条件；25,415名儿童参加了登记和测试；25%的儿童RSV阳性，14%的儿童流感阳性。2020年，我们注意到在引入社区缓解措施后，符合条件的和登记的ARI受试者减少，2020年4/5-4/30没有检测到RSV或流感。与2016-2019年相比，在2020年社区缓解期间，每个地点的合格ARI病例/周平均减少10.6例，RSV和流感检测呈阳性的几率分别降低63.9%和45.8%。在除西雅图以外的所有地点，2020年社区缓解期间RSV和流感阳性的比例低于预期。2020年3月至4月，美国七个城市的ARI病例以及RSV和流感在儿童中的比例持续快速下降，这可能要归功于社区对SARS-CoV-2采取的缓解措施。这项前瞻性的多中心监测研究评估了美国七个城市在新冠肺炎大流行之前和期间儿童急性呼吸窘迫综合征的频率。
Non-pharmaceutical interventions against COVID-19 likely have a role in decreasing viral acute respiratory illnesses (ARI). This study aimed to assess the frequency of respiratory syncytial virus (RSV) and influenza ARI in children, before and during the COVID-19 pandemic. This study was a prospective, multicenter, population-based ARI surveillance, including children <18 years presenting with fever and/or respiratory symptoms to emergency departments (ED) and inpatient settings in seven United States (US) cities. Respiratory samples were collected and evaluated by molecular testing. Data were analyzed by calendar weeks. Generalized linear mixed-effects models were used to evaluate the association between community mitigation and number of eligible cases, and proportion testing positive for RSV and influenza. Overall, 45,759 children were eligible; 25,415 were enrolled and tested; 25% were RSV-positive, and 14% were influenza-positive. In 2020, we noted a decrease in eligible and enrolled ARI subjects after community mitigation measures were introduced, with no RSV or influenza detection in 4/5-4/30/2020. Compared to 2016–2019, there was an average of 10.6 fewer eligible ARI cases/week per site and 63.9% and 45.8% lower odds of testing positive for RSV and influenza, respectively, during the 2020 community mitigation period. In all sites except Seattle, the proportions of positive RSV and influenza in the 2020 community mitigation period were lower than predicted. In March-April 2020, rapid declines in ARI cases and the proportions of RSV and influenza in children were consistently noted across seven US cities, which could be attributable to community mitigation measures against SARS-CoV-2. This prospective, multicenter, surveillance study evaluates the frequency of ARI in children before and during the COVID-19 pandemic within seven cities in the United States.