Pharmacological induction of physiologically active nerve growth factor in rat peripheral nervous system.
Pharmacological induction of physiologically active nerve growth factor in rat peripheral nervous system.
复制标题
大鼠周围神经系统生理活性神经生长因子的药理诱导。
DOI：
--
复制
发表时间：
1994
影响因子：
3.5
通讯作者：
S. Furukawa
中科院分区：
文献类型：
--
作者：
K. Kaechi;Y. Furukawa;R. Ikegami;N. Nakamura;F. Omae;Y. Hashimoto;K. Hayashi;S. Furukawa
Intraperitoneal administration of 4-methylcatechol, which is one of the potent stimulators of nerve growth factor (NGF) synthesis in vitro, induced an increase in NGF protein and NGF mRNA in the adult rat heart and submaxillary gland. The increase in NGF protein was successively translocated from the sciatic nerve to sensory or sympathetic ganglia. Repetitive administration of 1,2-diacetoxypropylbenzene, an acetylated form of 4-methylcatechol analog, caused significant elevations of substance P levels in sensory ganglia and tyrosine hydroxylase activity in superior cervical ganglia of infant rats. These observations suggest that both compounds could stimulate NGF synthesis in vivo and that the induced NGF had physiological effects on peripheral neurons.
