Morphological evidence for biological control of urate crystal formation in vivo and in vitro.
Morphological evidence for biological control of urate crystal formation in vivo and in vitro.
复制标题
体内和体外尿酸盐晶体形成生物控制的形态学证据。
DOI：
--
复制
发表时间：
1992
影响因子：
2.1
通讯作者：
P. Dieppe
中科院分区：
文献类型：
--
作者：
N. McGill;A. Hayes;P. Dieppe
尿酸盐结晶形成和随后的痛风仅发生在少数高尿酸血症受试者中，表明除高尿酸血症外还涉及其他因素。生物物质（特别是蛋白质）在体外改变晶体生长，与尿酸浓度无关。已知在生物控制下的生理晶体形成在形态上以尺寸的均匀性和晶体形状的约束为特征。为了确定病理性尿酸盐晶体的形成是否受到周围生物环境的影响，我们使用扫描电子显微镜检查了体内或体外形成的尿酸盐晶体的形态。我们发现了体内尿酸盐晶体形成的生物控制的形态学证据，并证明了这些特征可以通过在晶体形成期间向生长培养基中加入血清、滑液和某些血清蛋白在体外诱导。尿酸盐晶体的形成不仅取决于高尿酸血症的程度，还取决于周围的生物环境。
Urate crystal formation, and subsequent gout, occurs in only a minority of hyperuricaemic subjects indicating that factors other than hyperuricaemia are involved. Biological substances (especially proteins) alter crystal growth in vitro independently of uric acid concentration. Physiological crystal formation, known to be under biological control, is characterised morphologically by uniformity of size and constraint of crystal shape. To determine whether pathological urate crystal formation is influenced by the surrounding biological milieu we examined, using scanning electron microscopy, the morphology of urate crystals formed either in vivo or in vitro. We found morphological evidence of biological control of in vivo urate crystal formation and demonstrated that those characteristics could be induced in vitro by the addition of serum, synovial fluid and certain serum proteins to the growth medium during crystal formation. Urate crystal formation is dependent, not only on the degree of hyperuricaemia, but also on the surrounding biological milieu.
含有脱辅基蛋白 B 的脂蛋白是中性粒细胞对尿酸钠晶体反应的主要调节因子。
DOI：
10.1172/jci111380
发表时间：
1984
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Terkeltaub,R;Curtiss,LK;Tenner,AJ;Ginsberg,MH
通讯作者：
Ginsberg,MH