Natural Killer Cell Diversity in Viral Infection: Why and How Much?
Natural Killer Cell Diversity in Viral Infection: Why and How Much?
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DOI：
10.20411/pai.v1i1.142
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发表时间：
2016
影响因子：
--
通讯作者：
Blish CA
中科院分区：
文献类型：
--
作者：
Blish CA
自然杀伤细胞是一组不同的先天淋巴细胞，专门对癌细胞或病毒感染的细胞做出快速反应。 NK 细胞功能由细胞表面表达的激活和抑制受体信号的整合控制。这些激活和抑制受体在单细胞水平上的多样化表达模式导致 NK 细胞库高度多样化。在这里，我回顾了影响 NK 细胞库多样性的因素及其对我们对抗病毒能力的功能影响。
Natural killer cells are a diverse group of innate lymphocytes that are specialized to rapidly respond to cancerous or virus-infected cells. NK cell function is controlled by the integration of signals from activating and inhibitory receptors expressed at the cell surface. Variegated expression patterns of these activating and inhibitory receptors at the single cell level leads to a highly diverse NK cell repertoire. Here I review the factors that influence NK cell repertoire diversity and its functional consequences for our ability to fight viruses.