Pretreatment prognostic factors in patients with early-stage (I/II) non-small-cell lung cancer treated with hyperfractionated radiation therapy alone
Pretreatment prognostic factors in patients with early-stage (I/II) non-small-cell lung cancer treated with hyperfractionated radiation therapy alone
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DOI：
10.1016/j.ijrobp.2006.01.044
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发表时间：
2006-07-15
影响因子：
7
通讯作者：
Milisavljevic, Slobodan
中科院分区：
文献类型：
--
作者：
Jeremic, Branislav;Milicic, Biljana;Milisavljevic, Slobodan
目的：探讨各种预处理预后因素对早期（I/II）非小细胞肺癌（NSCLC）患者单用超分割放疗的影响。患者和方法：116例患者接受肿瘤剂量69.6戈伊，1.2-戈伊，每日2次分割治疗。有49例患者为I期，67例患者为II期。80例患者的Karnofsky体力状态（KPS）为90-100，95例患者体重减轻< 5%。在57例患者中观察到外周肿瘤。结果：本组患者中位生存时间为29个月，5年生存率为29%。局部进展和远处转移的中位时间未达到，而5年局部无进展和无远处转移生存率分别为50%和72%。多变量分析确定KPS、体重减轻、位置、组织学和不接受手术的原因为生存的预后因素。KPS，位置和组织学影响局部无进展生存，而只有KPS和体重减轻影响远处无转移survival.Conclusions：这项回顾性分析确定KPS和体重减轻作为最重要的预后因素的结果与超分割放射治疗早期非小细胞肺癌患者。(c)2006年爱思唯尔公司
Purpose: To investigate influence of various pretreatment prognostic factors in patients with early stage (I/II) non-small-cell lung cancer (NSCLC) treated with hyperfractionated radiation therapy alone.Patients and Methods: One hundred and sixteen patients were treated with tumor doses of 69.6 Gy, 1.2-Gy, twice-daily fractionation. There were 49 patients with Stage I and 67 patients with Stage II. Eighty patients had Karnofsky performance status (KPS) 90-100 and 95 patients had < 5% weight loss. Peripheral tumors were observed in 57 patients. Squamous histology was observed in 70 patients and the majority of patients had concomitant disease (n = 72).Results: The median survival time for all patients was 29 months; 5-year survival was 29%. The median time to local progression and the distant metastasis were not achieved, whereas 5-year local progression-free and distant metastasis-free survivals were 50% and 72%, respectively. Multivariate analysis identified KPS, weight loss, location, histology, and the reason for not undergoing surgery as prognostic factors for survival. KPS, location, and histology influenced local progression-free survival, whereas only KPS and weight loss influenced distant metastasis-free survival.Conclusions: This retrospective analysis identified KPS and weight loss as the most important prognostic factors of outcome in patients with early-stage NSCLC treated with hyperfractionation radiation therapy. (c) 2006 Elsevier Inc.