Dietary triglycerides as signaling molecules that influence reward and motivation.
Dietary triglycerides as signaling molecules that influence reward and motivation.
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DOI：
10.1016/j.cobeha.2016.03.005
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发表时间：
2016-06
影响因子：
5
通讯作者：
Luquet S
中科院分区：
文献类型：
--
作者：
Berland C;Cansell C;Hnasko TS;Magnan C;Luquet S
食物的强化和激励方面与中脑边缘系统(ML)中多巴胺的释放有关。富含甘油三酯(TG)的颗粒中的游离脂肪酸在外周氧化组织(肌肉、心脏)中发现高水平的TG-脂肪酶作用后释放，但也存在于ML中。这表明ML中的局部TG-水解酶可能调节食物的寻找和奖励。事实上，现在的证据表明，饮食中的甘油三酯直接针对ML来调节安非他明诱导的运动和寻求奖励的行为。尽管TG作用的细胞机制尚不清楚，但TG部分通过位于多巴胺2受体(D2R)上游的ML脂蛋白脂酶起作用，并在肥胖患者血浆TG长期升高的情况下表现出脱敏作用。因此，ML中的TG感应代表了一种新的机制，通过这种机制，长期摄入膳食脂肪可能会导致ML的适应和失调的摄食行为。
The reinforcing and motivational aspects of food are tied to the release of the dopamine in the mesolimbic system (ML). Free fatty acids from triglyceride (TG)-rich particles are released upon action of TG-lipases found at high levels in peripheral oxidative tissue (muscle, heart), but also in the ML. This suggests that local TG-hydrolysis in the ML might regulate food seeking and reward. Indeed, evidence now suggests that dietary TG directly target the ML to regulate amphetamine-induced locomotion and reward seeking behavior. Though the cellular mechanisms of TG action are unresolved, TG act in part through ML lipoprotein lipase, upstream of dopamine 2 receptor (D2R), and show desensitization in conditions of chronically elevated plasma TG as occur in obesity. TG sensing in the ML therefore represents a new mechanism by which chronic consumption of dietary fat might lead to adaptations in the ML and dysregulated feeding behaviors.