Analysis of secreted peptidome from omental adipose tissue in polycystic ovarian syndrome patients
Analysis of secreted peptidome from omental adipose tissue in polycystic ovarian syndrome patients
复制标题
多囊卵巢综合征患者大网膜脂肪组织分泌肽的分析
DOI：
10.1002/jcp.26393
复制
发表时间：
2018-08-01
影响因子：
5.6
通讯作者：
Xu, Pengfei
中科院分区：
文献类型：
--
作者：
Jia, Genmei;Tao, Hongjiang;Xu, Pengfei
多囊卵巢综合征（PCOS）是一种常见的内分泌疾病，与代谢紊乱的风险增加有关。患多囊症的妇女肥胖的患病率更高。此外，脂肪组织功能障碍已在PCOS患者中得到证实，特别是腹部脂肪组织。这种功能障碍可能会加剧代谢和生殖异常。我们使用液相色谱-质谱法比较多囊卵巢综合征和非多囊卵巢综合征腹部脂肪组织分泌的肽。我们检测到298个上调肽和31个下调肽(绝对折叠变化e2和p
Polycystic ovarian syndrome (PCOS) is a common endocrinopathy associated with increased risk of metabolic disorders. Prevalence of adiposity and obesity is greater in women suffering from PCOS. Moreover, adipose tissue dysfunction has been demonstrated in PCOS patients, particularly in abdominal adipose tissue. This dysfunction likely aggravates the metabolic and reproductive abnormalities. We used liquid chromatography-mass spectrometry to compare the peptides secreted from PCOS and non-PCOS abdominal adipose tissue. We detected 298 upregulated peptides and 31 downregulated peptides (absolute fold change2 and p