Integracides H-J: New tetracyclic triterpenoids from the endophytic fungus Fusarium sp.
Integracides H-J: New tetracyclic triterpenoids from the endophytic fungus Fusarium sp.
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DOI：
10.1016/j.fitote.2016.06.002
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发表时间：
2016-07-01
期刊：
影响因子：
3.4
通讯作者：
Ross, Samir A.
中科院分区：
文献类型：
--
作者：
Ibrahim, Sabrin R. M.;Abdallah, Hossam M.;Ross, Samir A.
从沙特阿拉伯长叶薄荷（Mentha longifolia L (Labiatae)）根内生真菌镰刀菌（Fusarium sp.）中分离到三个新的四环三萜，即整合酸酯H(1)、I(4)和J(5)，以及整合酸酯B(3)和F(2)。通过UV、IR、1D （H-1和C-13）和2D (H-1-H-1 COSY、TOCSY、HSQC、HMBC和NOESY) NMR、HRESIMS等光谱分析和文献资料比对，对分离得到的化合物进行了结构解析。整合酸酯H(1)和J(5)对多诺瓦利什曼原虫的IC50值分别为4.75和329 μ M，而喷他脒的IC50值为6.35 μ M。此外，它们对BT-549、SKOV-3和KB细胞系表现出较强的细胞毒活性，IC50值分别为1.82、132和0.18 μ M, 2.46、3.01和2.54 μ M。(C) 2016 Elsevier B.V.版权所有
Three new tetracyclic triterpenoids namely, integracides H (1), I (4), and J (5), along with integracides B (3) and F (2) have been isolated from the endophytic fungus Fusarium sp. isolated from the roots of Mentha longifolia L (Labiatae) growing in Saudi Arabia. The structure elucidation of the isolated compounds was achieved by spectroscopic analysis including UV, IR, 1D (H-1 and C-13) and 2D (H-1-H-1 COSY, TOCSY, HSQC, HMBC, and NOESY) NMR as well as HRESIMS and comparison with literature data. Integracides H (1) and J (5) showed significant anti-leishmanial activity towards Leishmania donovani with IC50 values of 4.75 and 329 mu M, respectively compared to pentamidine (IC50 6.35 mu M). Moreover, they displayed potent cytotoxic activity towards BT-549, SKOV-3, and KB cell lines with IC50 values of 1.82, 132, and 0.18 mu M and 2.46, 3.01, and 2.54 mu M, respectively. (C) 2016 Elsevier B.V. All rights reserved.