The Xenopus ortholog of the nuclear hormone receptor Nr2e3 is primarily expressed in developing photoreceptors
The Xenopus ortholog of the nuclear hormone receptor Nr2e3 is primarily expressed in developing photoreceptors
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DOI：
10.1387/ijdb.062236rm
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发表时间：
2007-01-01
影响因子：
0.7
通讯作者：
El-Hodiri, Heithem M.
中科院分区：
文献类型：
--
作者：
Martinez-De Luna, Reyna I.;El-Hodiri, Heithem M.
NR2e3是一种参与视杆细胞分化的核激素受体。Nr2e3基因先前在人类、小鼠、斑马鱼和鸡中被发现。在所有物种中，Nr2e3表达仅限于视网膜，并且被认为在视杆细胞的特化和维持中具有作用。在这里，我们报告的非洲爪蟾Nr2e3的识别和表征。我们发现Nr2e3主要在发育中的视杆细胞中表达。与其他物种相比，Nr2e3在非洲爪蟾发育过程中也在脊索和松果体中表达。
Nr2e3 is a nuclear hormone receptor that is involved in rod photoreceptor differentiation. The Nr2e3 gene was previously identified in humans, mice, zebrafish and chicken. In all species, Nr2e3 expression is restricted to the retina and is believed to have a role in rod photoreceptor specification and maintenance. Here we report the identification and characterization of the Xenopus Nr2e3. We found that Nr2e3 is primarily expressed in developing rod photoreceptors. In contrast to other species, Nr2e3 is also expressed in the notochord and pineal gland during Xenopus laevis development.