In vitro and in vivo evaluation of a Cu-64-labeled propylene amine oxime complex as a potential hypoxia imaging agent bearing two 3-nitrotriazole groups
In vitro and in vivo evaluation of a Cu-64-labeled propylene amine oxime complex as a potential hypoxia imaging agent bearing two 3-nitrotriazole groups
复制标题
Cu-64 标记的丙胺肟复合物作为带有两个 3-硝基三唑基团的潜在缺氧显像剂的体外和体内评估
DOI：
10.1007/s10967-017-5345-4
复制
发表时间：
2017
影响因子：
1.6
通讯作者：
Chu Taiwei
中科院分区：
文献类型：
--
作者：
Zhang Wei;Zhang Qiang;Chen Qingxin;Zhu Hua;Yang Zhi;Chu Taiwei
用64 CuCl 2标记了丙烯胺肟（PnAO）配体PnAO-1，1′-双（3-硝基三唑）（3 P3）。体外实验结果表明，64 Cu-3 P3可在缺氧的S180肿瘤细胞中蓄积。~（64）Cu-3P_3在荷S180肿瘤小鼠体内的生物分布研究表明，肿瘤摄取、肿瘤-肌肉比和肿瘤-血液比是相当大的。在给药后18小时的正电子发射断层扫描成像中也可以发现肿瘤区域。作为对比，还研究了经典的乏氧显像剂64 Cu-ATSM。实验结果表明，~（64）Cu-3P_3有可能成为一种有效的乏氧显像剂。
The propylene amine oxime (PnAO) ligand, PnAO-1, 1′-bis(3-nitrotriazole) (3P3) with two 3-nitrotriazole groups was labeled with64CuCl2. In vitro results suggest that64Cu-3P3 can accumulate in hypoxic S180 tumor cells. Biodistribution studies of64Cu-3P3 in mice bearing S180 tumor demonstrate that the tumor uptake, tumor-to-muscle ratio, and tumor-to-blood ratio are considerable. A tumor area could also be found in positron emission tomography imaging 18 h post-administration. For comparison, the classical hypoxia imaging agent64Cu-ATSM was also investigated. The experimental data obtained demonstrate that64Cu-3P3 may potentially be used as an efficient hypoxia imaging agent.