The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.
The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.
复制标题
三种小鼠多药耐药（mdr）基因在正常小鼠组织中以组织特异性方式表达。
DOI：
10.1128/mcb.9.3.1346-1350.1989
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发表时间：
1989
影响因子：
5.3
通讯作者：
Housman,DE
中科院分区：
文献类型：
--
作者：
Croop,JM;Raymond,M;Haber,D;Devault,A;Arceci,RJ;Gros,P;Housman,DE
The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinctmdrgene transcripts encoded by three separatemdrgenes in the mouse. Expression levels of eachmdrgene are dramatically different in various mouse tissues. SpecificmdrRNA transcripts of approximately 4.5, 5, and 6 kilobases have been detected. Each of themdrgenes has a specific RNA transcript pattern. These results should be considered in relation to understanding the normal physiological function of themdrmultigene family.
