Primary motor cortex activation by transcranial direct current stimulation in the human brain
Primary motor cortex activation by transcranial direct current stimulation in the human brain
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DOI：
10.1016/j.neulet.2008.02.012
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发表时间：
2008-04-11
影响因子：
2.5
通讯作者：
Jang, Sung Ho
中科院分区：
文献类型：
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作者：
Kwon, Yong Hyun;Ko, Myoung-Hwan;Jang, Sung Ho
经颅直流电刺激（tDCS）可以调节人脑运动皮层的兴奋性。我们试图用功能性MRI（fMRI）证明tDCS对初级运动皮层（M1）的皮层刺激作用。对11名右利手的健康受试者在1.5T下进行了fMRI研究。将阳极tDCS应用于左半球中的MI的中央旋钮上方的头皮。施加强度为1.0 mA的恒定电流。总的fMRI范例包括三个会话，每个会话之间有5分钟的休息期。每个阶段由五个连续阶段组成（静息-tDCS-tDCS-tDCS-tDCS），每个阶段进行21 s。我们的研究结果显示，除了第四tDCS阶段，在任何刺激阶段都没有检测到皮层激活。在第四tDCS阶段的组分析结果中，平均图表明左侧初级运动皮层的中央结被激活。此外，左侧辅助运动皮层和右侧后顶叶皮层也有激活。我们证明了tDCS对底层皮层具有直接刺激作用。似乎tDCS是用于刺激目标皮层区域的有用方式。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Transcranial direct current stimulation (tDCS) can modulate motor cortex excitability in the human brain. We attempted to demonstrate the cortical stimulation effect of tDCS on the primary motor cortex (M1) using functional MRI (fMRI). An fMRI study was performed for 11 right-handed healthy subjects at 1.5 T. Anodal tDCS was applied to the scalp over the central knob of the M I in the left hemisphere. A constant current with an intensity of 1.0 mA was applied. The total fMRI paradigm consisted of three sessions with a 5-min resting period between each session. Each session consisted of five successive phases (resting-tDCS-tDCS-tDCS-tDCS), and each of the phases was performed for 21 s. Our findings revealed that no cortical activation was detected in any of the stimulation phases except the fourth tDCS phase. In the result of group analysis for the fourth tDCS phase, the average map indicated that the central knob of the left primary motor cortex was activated. In addition, there were activations on the left supplementary motor cortex and the right posterior parietal cortex. We demonstrated that tDCS has a direct stimulation effect on the underlying cortex. It seems that tDCS is a useful modality for stimulating a target cortical region. (C) 2008 Elsevier Ireland Ltd. All rights reserved.