Effect of the dopamine D3 receptor antagonist GSK598809 on brain responses to rewarding food images in overweight and obese binge eaters
Effect of the dopamine D3 receptor antagonist GSK598809 on brain responses to rewarding food images in overweight and obese binge eaters
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DOI：
10.1016/j.appet.2012.03.007
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发表时间：
2012-08-01
期刊：
影响因子：
5.4
通讯作者：
Nathan, Pradeep J.
中科院分区：
文献类型：
--
作者：
Dodds, Chris M.;O'Neill, Barry;Nathan, Pradeep J.
多巴胺D-3受体被认为是治疗强迫症如药物成瘾和肥胖的潜在靶点。在这里，我们使用功能性磁共振成像（fMRI），以调查的影响，选择性多巴胺D-3受体拮抗剂GSK 598809对大脑激活的食物图像在超重和肥胖暴饮暴食受试者的样本。与先前的研究一致，食物图像的处理与包括杏仁核、纹状体和杏仁核在内的奖赏区域网络的激活有关。然而，大脑激活的食物图像没有调制的GSK 598809。结果表明，D-3受体操纵不调节大脑对超重和肥胖受试者食物图像的反应。(C)2012爱思唯尔有限公司保留所有权利。
The dopamine D-3 receptor is thought to be a potential target for treating compulsive disorders such as drug addiction and obesity. Here, we used functional Magnetic Resonance Imaging (fMRI) to investigate the effects the selective dopamine D-3 receptor antagonist GSK598809 on brain activation to food images in a sample of overweight and obese binge-eating subjects. Consistent with previous studies, processing of food images was associated with activation of a network of reward areas including the amygdala, striatum and insula. However, brain activation to food images was not modulated by GSK598809. The results demonstrate that D-3 receptor manipulation does not modulate brain responses to food images in overweight and obese subjects. (C) 2012 Elsevier Ltd. All rights reserved.