Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease
Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease
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DOI：
10.1001/archneur.63.11.1602
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发表时间：
2006-11-01
影响因子：
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通讯作者：
Miniussi, Carlo
中科院分区：
文献类型：
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作者：
Cotelli, Maria;Manenti, Rosa;Miniussi, Carlo
目的：评估重复经颅磁刺激（rTMS）背外侧前额叶皮层（DLPFC）对阿尔茨海默病（AD）患者图片命名的影响。设计：实验研究。AD患者在图片命名任务期间在真实的和对照条件下进行rTMS。设置：意大利布雷西亚的San Giovanni di Dio Fatebenefratelli科学研究所。患者：15名可能患有AD的患者。干预：高频rTMS应用于左和右DLPFC在物体和动作naming.Main结果Measures：语言能力进行了评估的言语反应的准确性在线rTMS。结果：刺激左和右DLPFC提高动作命名的准确性。结论：这些发现表明，对DLPFC进行rTMS，可以加快正常对照组的动作命名，提高AD患者的表现。虽然rTMS诱导的命名促进这些患者的机制是未知的，该程序可能是值得测试作为一种新的方法来治疗语言功能障碍。
Objective: To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD).Design: Experimental study.Patients with AD under went rTMS in real and control conditions during picture naming tasks.Setting: San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy.Patients: Fifteen patients with probable AD.Intervention: High-frequency rTMS was applied to the left and right DLPFC during object and action naming.Main Outcome Measures: Language ability was assessed by accuracy of verbal response during online rTMS.Results: Stimulation to the left and right DLPFC improved accuracy in action naming.Conclusions: These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.