P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation
P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation
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DOI：
10.1101/cshperspect.a012286
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发表时间：
2012-09-01
影响因子：
7.2
通讯作者：
Parker, Roy
中科院分区：
文献类型：
--
作者：
Decker, Carolyn J.;Parker, Roy
在真核基因表达的调控中，翻译和mRNA降解的控制是重要的。总的来说，翻译和步骤是相互竞争的，是mRNA衰变的主要途径。不参与翻译的mRNAs可以聚集成胞质mRNP颗粒，称为加工体(P体)和应激颗粒，与控制早期发育和神经元翻译的mRNP颗粒有关。对P小体和应激颗粒的分析表明，mRNP是一个动态过程，称为mRNA循环，在这个过程中，mRNP可以在多聚体、P小体和应激颗粒之间移动，尽管mRNP组装成高阶结构的功能尚不清楚。在这篇文章中，我们综述了翻译和mRNA降解的耦合，P小体和应激颗粒的特性，以及mRNPs组装成更大的结构如何影响细胞功能。
The control of translation and mRNA degradation is important in the regulation of eukaryotic gene expression. In general, translation and steps in the major pathway of mRNA decay are in competition with each other. mRNAs that are not engaged in translation can aggregate into cytoplasmic mRNP granules referred to as processing bodies (P-bodies) and stress granules, which are related to mRNP particles that control translation in early development and neurons. Analyses of P-bodies and stress granules suggest a dynamic process, referred to as the mRNA Cycle, wherein mRNPs can move between polysomes, P-bodies and stress granules although the functional roles of mRNP assembly into higher order structures remain poorly understood. In this article, we review what is known about the coupling of translation and mRNA degradation, the properties of P-bodies and stress granules, and how assembly of mRNPs into larger structures might influence cellular function.