Coordination of leaf development via regulation of KNOX1 genes
Coordination of leaf development via regulation of KNOX1 genes
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DOI：
10.1007/s10265-009-0248-2
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发表时间：
2009
影响因子：
2.8
通讯作者：
N. Uchida;S. Kimura;Daniel Koenig;N. Sinha
中科院分区：
文献类型：
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作者：
N. Uchida;S. Kimura;Daniel Koenig;N. Sinha
KNOX1类同源异型盒(KNOX1)基因在顶端分生组织(SAM)中表达，影响其形成和维持。KNOX1基因还参与被子植物进化过程中的叶形控制。叶片可分为单叶和复叶两类，KNOX1基因在叶原基中的表达模式与叶形高度相关；在大多数单叶植物中，KNOX1基因只在叶原基中表达而在叶原基中不表达，而在复叶物种中，KNOX1基因在叶原基和SAM中都有表达。如何在SAM中保持KNOX1的高度表达，而同时在叶片中保持如此可变的表达？这种二分法表明，在进化过程中，叶和SAM的发育过程被划分为不同的过程。在这里，我们介绍了我们关于KNOX1基因表达调控的研究结果，并从进化的角度对KNOX1基因进行了简要的综述。我们还介绍了我们关于KNOX1调控的另一个方面的发现，这是通过参与叶片形状自然变化的蛋白质-蛋白质相互作用网络来实现的。KNOX1调控的这两个方面都可用于微调进化过程中的叶片形态，而不影响KNOX基因在地上部的基本功能。
Class IKNOTTED1-LIKE HOMEOBOX(KNOX1) genes are expressed in the shoot apical meristem (SAM) to effect its formation and maintenance.KNOX1genes are also involved in leaf shape control throughout angiosperm evolution. Leaves can be classified as either simple or compound, andKNOX1expression patterns in leaf primordia are highly correlated with leaf shape; in most simple-leafed species,KNOX1genes are expressed only in the SAM but not in leaf primordia, while in compound-leafed species they are expressed both in the SAM and leaf primordia. How canKNOX1expression be maintained to a high degree in the SAM, but simultaneously be so variable in leaves? This dichotomy suggests that the processes of leaf and SAM development have been compartmentalized during evolution. Here, we introduce our findings regarding the regulation of expression ofSHOOT MERISTEMLESS, aKNOX1gene, together with a brief review ofKNOX1genes from an evolutionary viewpoint. We also present our findings regarding another aspect ofKNOX1regulation via a protein–protein interaction network involved in the natural variation in leaf shape. Both aspects ofKNOX1regulation could be utilized for fine-tuning leaf morphology during evolution without affecting the essential function ofKNOXgenes in the shoot.