Testosterone replacement therapy and polycythemia in HIV-infected patients.
Testosterone replacement therapy and polycythemia in HIV-infected patients.
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HIV 感染患者的睾酮替代疗法和红细胞增多症。
DOI：
10.1097/qad.0b013e32834db446
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Glesby,MarshallJ
中科院分区：
文献类型：
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作者：
Vorkas,CharlesKyriakos;Vaamonde,CarlosM;Glesby,MarshallJ
我们进行了一项病例对照研究，以评估睾酮使用作为21例HIV感染男性红细胞增多症的主要危险因素。在首次血红蛋白升高的2个月内使用任何睾酮与红细胞增多症相关（匹配比值比6.55; 95%置信区间1.83-23.4; P= 0.004），肌肉注射比局部使用具有更强的相关性。未观察到不良心血管或血栓形成事件。服用睾酮的HIV感染患者应进行常规血液学监测，并在适当时调整治疗。
We conducted a case–control study to assess testosterone use as a primary risk factor for polycythemia in 21 HIV-infected men. Any testosterone use within 2 months of first elevated hemoglobin was associated with polycythemia (matched odds ratio 6.55; 95% confidence interval 1.83–23.4; P= 0.004) and intramuscular administration demonstrated a stronger association than topical use. No adverse cardiovascular or thrombotic events were observed. HIV-infected patients taking testosterone should undergo routine hematologic monitoring with adjustment of therapy when appropriate.