Evaluation of radiation-induced liver injury with MR imaging: comparison of hepatocellular and reticuloendothelial contrast agents.
Evaluation of radiation-induced liver injury with MR imaging: comparison of hepatocellular and reticuloendothelial contrast agents.
复制标题
磁共振成像评估辐射引起的肝损伤：肝细胞和网状内皮造影剂的比较。
DOI：
10.1148/radiology.185.1.1523301
复制
发表时间：
1992
期刊：
影响因子：
19.7
通讯作者：
Brasch,RC
中科院分区：
文献类型：
--
作者：
Clément,O;Mühler,A;Vexler,VS;Rosenau,W;Berthezène,Y;Kuwatsuru,R;Brasch,RC
比较了肝细胞定向磁共振造影剂钆(4s)-4-(4-乙氧基苯基-3,6,9-三（羧基-甲基）-3,6,9-三氮杂二酸（EOB）二乙基三胺五乙酸（DTPA）和库普弗细胞定向造影剂包裹超顺磁性氧化铁颗粒（SPIO）在啮齿动物辐射肝损伤模型中的吸收和增强效果。18只大鼠肝脏一侧接受单次x射线照射（50-70 Gy）。在同一只大鼠连续注射两种造影剂x射线照射后3天进行MR成像。此外，测定5只大鼠全肝辐照后Gd-EOB-DTPA的胆汁排泄量。电子显微镜下的辐照肝脏显示线粒体损伤的肝细胞和库普弗细胞群。然而，Gd-EOB-DTPA的肝增强和胆汁排泄不受照射的影响。SPIO的摄取在肝脏的辐照部分减少，在MR成像中辐照区和非辐照区之间有精确的界限。
Gadolinium (4s)-4-(4-ethoxybenzyl-3,6,9-tris(carboxylato-methyl)-3,6,9- triazaudecandioic acid (EOB) diethylenetriaminepentaacetic acid (DTPA), a hepatocellular-directed magnetic resonance (MR) contrast agent, and coated superparamagnetic iron oxide particles (SPIO), a Kupffer cell-directed contrast agent, were compared for uptake and enhancement in a rodent model of radiation-induced liver injury. A single x-irradiation exposure (50-70 Gy) was delivered to one side of the liver in 18 rats. MR imaging was performed 3 days after x irradiation with sequential injections of the two contrast agents in the same rats. Additionally, biliary excretion of Gd-EOB-DTPA was quantified after whole-liver irradiation in five rats. Electron microscopy of the irradiated liver demonstrated mitochondrial injury in both hepatocyte and Kupffer cell populations. With Gd-EOB-DTPA, however, liver enhancement and biliary excretion were not affected by irradiation. Uptake of SPIO was decreased in the irradiated portion of the liver, with a precise demarcation between irradiated and nonirradiated zones at MR imaging.