HEDONIC REACTIVITY TO SUCROSE IN RATS - MODIFICATION BY PIMOZIDE
HEDONIC REACTIVITY TO SUCROSE IN RATS - MODIFICATION BY PIMOZIDE
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DOI：
10.1016/0031-9384(86)90409-9
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发表时间：
1986-01-01
影响因子：
2.9
通讯作者：
KING, JE
中科院分区：
文献类型：
--
作者：
BAILEY, CS;HSIAO, S;KING, JE
奖赏总和函数是分离和量化抗精神病药物的享乐效应和运动效应的重要方法。以前只使用脑刺激强化，我们证明他们也将使用蔗糖溶液强化工作。对18只雄性大鼠进行训练，使其按CRF时间表对不同浓度（0.025、0.05、0.1、0.3、0.5、0.7、0.9、1.1、1.7、2.3 M）的0.01 ml蔗糖溶液进行杠杆按压。使杠杆更难按下导致函数的渐近线增加，证明了运动效应。奎宁添加到溶液（0.05%）导致功能右移，表现出享乐效应。注射0.2 mg/kg匹莫齐特的大鼠。四小时后测试多巴胺拮抗剂，显示功能右移，渐近线没有变化。因此，在该剂量下，匹莫齐特影响中枢神经系统的享乐底物而非运动底物。这些数据证明了RSF方法对大脑自刺激以外的其他刺激的普遍性。
Reward summation functions (RSFs) are an important way to dissociate and quantify hedonic and motor effects of neuroleptics. Previously used only with brain stimulation reinforcement, we demonstrate they will also work using sucrose solution reinforcement. Eighteen male rats were trained to lever press on a CRF schedule for 0.01 ml sucrose solution reinforcers of varying concentration (0.025, 0.05, 0.1, 0.3, 0.5, 0.7, 0.9, 1.1, 1.7, 2.3 M). Making the lever harder to press caused an increase in the asymptote of the function, demonstrating a motor effect. Quinine added to the solution (0.05%) caused the function to shift right, demonstrating an hedonic effect. Rats injected with 0.2 mg/kg pimozide. a dopamine antagonist, then, tested four hours later, showed a right shift in the function with no change in asymptote. Thus, at this dose pimozide affects hedonic and not motor substrates of the CNS. These data demonstrate the generalizability of the RSF method to reinforcers other than brain self-stimulation.