Defining hormone replacement therapy in longitudinal studies: impact on measures of effect.
Defining hormone replacement therapy in longitudinal studies: impact on measures of effect.
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在纵向研究中定义激素替代疗法：对效果测量的影响。
DOI：
10.1002/pds.844
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Hanley,JamesA
中科院分区：
文献类型：
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作者：
Csizmadi,Ilona;Collet,Jean-Paul;Benedetti,Andrea;Boivin,Jean-Francois;Hanley,JamesA
分析了一项巢式病例对照研究的数据，旨在检查激素替代疗法（HRT）对结直肠癌风险的影响，以确定暴露定义对风险比（RR）估计的影响。处方药计划数据库用于确定在索引日期之前分配给病例（n= 3059）和年龄匹配对照（n= 12 116）的HRT处方。HRT暴露量定义为“处方”和“片剂”计数、“仅结合雌激素”和基于多种雌激素最低暴露量比例的方法（SUM-P3和SUM-P12）。HRT的效果是根据HRT使用的“曾经”、< 5年和≥ 5年来描述的。使用条件Logistic回归估计OR和95%置信区间（CI）。HRT“曾经使用”的调整OR范围为0.72（95%CI：0.60-0.88）至0.86（95%CI：0.76-0.99）;对于<5年的使用，从0.70（95%CI：0.56-0.88）至0.89（95%CI：0.78-1.01），HRT使用≥5年，从0.74（95%CI：0.59-0.92）至0.98（95%CI：0.42-2.26）。用于定义HRT暴露的各种方法产生了一系列估计的OR，这些OR在幅度上的变化类似于文献中报道的调查HRT与结直肠癌之间关联的观察性研究的结果。版权所有© 2003年约翰威利父子有限公司。
Data from a nested case‐control study, designed to examine the effect of hormone replacement therapy (HRT) on colorectal cancer risk, were analyzed to determine the effect of exposure definition on the estimation of risk ratios (RR). A prescription drug plan database was used to ascertain HRT prescriptions dispensed prior to index dates to cases (n= 3059) and age‐matched controls (n= 12 116). HRT exposure was defined as ‘prescription’ and ‘tablet’ counts, ‘conjugated estrogen only’ and a method based on proportions of minimum exposure to a number of estrogens (SUM‐P3 and SUM‐P12). The effect of HRT was described with reference to ‘ever’, < 5 and ≥ 5 years of HRT use. Conditional logistic regression was used to estimate ORs and 95% confidence intervals (CI). Adjusted ORs for ‘ever use’ of HRT ranged from 0.72 (95%CI: 0.60–0.88) to 0.86 (95%CI: 0.76–0.99); for <5 years use, from 0.70 (95%CI: 0.56–0.88) to 0.89 (95%CI: 0.78–1.01) and for ≥5 year of HRT use, from 0.74 (95%CI: 0.59–0.92) to 0.98 (95%CI: 0.42–2.26). Various methods used to define HRT exposure produce a range of estimated ORs that vary in magnitude similar to results reported in the literature from observational studies investigating the association between HRT and colorectal cancer. Copyright © 2003 John Wiley & Sons, Ltd.