EXCISION OF MELANOMA METASTASES TO LUNG - PROBLEMS IN DIAGNOSIS AND MANAGEMENT
EXCISION OF MELANOMA METASTASES TO LUNG - PROBLEMS IN DIAGNOSIS AND MANAGEMENT
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DOI：
10.1097/00000658-197312000-00005
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发表时间：
1973-01-01
影响因子：
9
通讯作者：
CAHAN, WG
中科院分区：
文献类型：
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作者：
CAHAN, WG
尽管黑色素瘤无疑是可怕的，尽管目前对影响其病程的机制一无所知，但它并不一定像人们普遍认为的那样致命。如果对原发灶进行彻底广泛切除，并且局部淋巴结未被转移灶累及，5年生存率可能上升到704**。如果局部淋巴结被累及并被切除，无论是在原发灶切除时还是在原发灶切除后，5年生存率至少有40%。然而，黑色素瘤的恶名并非毫无根据。这可能部分源于其异常不可预测的行为，这种行为往往以戏剧性和滑稽的方式表现出来。例如，在某些患者中，它似乎是自主的，因此非常小的浅表病变可以引起广泛的、大量的转移，并在短时间内使患者不堪重负。在其他情况下，肿瘤和宿主之间显然存在一种平衡，这种平衡可以维持10至15年或更长时间，此时癌症可能会死灰复燃，并无情地发展至导致死亡。
Although undoubtedly formidable, and despite the present ignorance of the mechanisms that influence its course, melanoma is not necessarily as deadly as is generally believed. If a thorough wide removal of the primary lesion is done, and the regional lymphatics remain uninvolved by metasases, the possibility for 5 year survival rises to 704****** If the regional lymphatics are ınvolved and are extirpated, either with or subsequent to the excision of the primary tumor, there is at least a 40 chance for 5 year survivalº However, melanoma's notoriety is not without founda-tion. It probably stems, in part, from its exceptionally unpredictable behaviour which often manifests itself in dramatic and antic ways. For instance, in some pa-tients it seems to be autonomous so that very small, superficial lesions can give rise to widespread, vol-uminous metastases and overwhelm the patient in a short time. In others, there is apparently a balance struck between the tumor and the host that can be maintained for 10 to 15 years or more, at which time the resurgence of the cancer can take place and progress inexorably to cause death.