Axial flow velocity patterns in a pulmonary artery model with varying degrees of valvular pulmonic stenosis: pulsatile in vitro studies.
Axial flow velocity patterns in a pulmonary artery model with varying degrees of valvular pulmonic stenosis: pulsatile in vitro studies.
复制标题
具有不同程度的瓣膜性肺动脉狭窄的肺动脉模型中的轴向流速模式：脉动体外研究。
DOI：
10.1016/0021-9290(90)90049-9
复制
发表时间：
1990
影响因子：
2.4
通讯作者：
Yoganathan,AP
中科院分区：
文献类型：
--
作者：
Sung,HW;Philpot,EF;Nanda,NC;Yoganathan,AP
随着非侵入性的临床技术，可以测量血流速度（多普勒超声）的出现，它建议，在肺动脉的轴向流速模式的基本知识，以及狭窄引起的变化，可用于支持准确诊断肺动脉瓣狭窄。本研究旨在描述不同程度肺动脉瓣狭窄的成人肺动脉体外模型的轴向流速模式。采用二维激光多普勒风速仪（LDA）系统绘制肺动脉模型主支（MPA）、左支（LPA）和右支（RPA）的流场。这项研究是在格鲁吉亚理工学院进行的。右心脉冲复制系统观察到MPA和LPA的轴向流速模式随着瓣膜狭窄程度的增加而发生显着变化。这表明这两个分支的轴向流速模式受到瓣膜狭窄程度的强烈影响。然而，RPA中的轴向流速模式并不随不同程度的瓣膜狭窄而改变，这表明RPA中的轴向流场主要受分叉几何形状的影响。因此，可以得出结论，MPA和LPA（而不是RPA）中的轴向流速模式的变化可能是缺陷严重程度的敏感和可靠指标。
With the advent of noninvasive clinical techniques which can measure blood flow velocities (Doppler ultrasound), it is suggested that a fundamental knowledge of the axial flow velocity patterns in the pulmonary artery, and the changes caused by stenosis, may be used to support accurate diagnosis of valvular pulmonic stenosis. The present study was designed to characterize the axial flow velocity patterns in anin vitromodel of a human adult pulmonary artery with varying degrees of valvular pulmonic stenosis. A two-dimensional laser Doppler anemometer (LDA) system was used to map the flow fields in the main (MPA), left (LPA), and right (RPA) branches of the pulmonary artery model. The study was conducted in the Georgia Tech. right heart pulse duplicator system. It was observed that the axial flow velocity patterns in the MPA and the LPA change dramatically with increasing degree of valvular stenosis. This indicates that the axial flow velocity patterns in these two branches are strongly influenced by the degree of valvular stenosis. The axial flow velocity patterns in the RPA, however, do not change much with varying degrees of valvular stenosis, indicating that the axial flow fields in the RPA are mainly influenced by the geometry of the bifurcation. It may be concluded therefore, that the changes in the axial flow velocity patterns in the MPA and LPA (rather than in the RPA) could be sensitive and reliable indicators of the severity of the defect.