Noninvasive assessment of baroreflex control in borderline hypertension. Comparison with the phenylephrine method.
Noninvasive assessment of baroreflex control in borderline hypertension. Comparison with the phenylephrine method.
复制标题
临界高血压压力反射控制的无创评估。
DOI：
10.1161/01.hyp.28.2.238
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Sherwood,A
中科院分区：
文献类型：
--
作者：
Watkins,LL;Grossman,P;Sherwood,A
在这项研究中，我们检查了两种最近开发的无创压力反射测量技术来评估高血压压力反射控制的敏感性。我们使用频谱分析和序列检测，根据收缩压和 RR 间期的协变，无创地评估了压力反射敏感性。将压力反射控制的无创估计值与血压正常受试者 (n=27) 和临界高血压受试者 (n=15) 中去氧肾上腺素引起的收缩压和 RR 间期增加的估计值进行比较。当使用非侵入性或侵入性方法来评估压力反射控制时，相对于血压正常组，临界高血压组的压力反射敏感性显着降低。此外，从非侵入性方法获得的估计值与用去氧肾上腺素方法评估的压力反射敏感性显着相关（光谱：r=.48，P<.001；序列：r=.50，P<.001）。这些发现表明，光谱分析和序列方法为估计高血压压力反射敏感性的药理学方法提供了可行的替代方案。
In this study, we examined the sensitivity of two recently developed noninvasive baroreflex measurement techniques to assess baroreflex control in hypertension. We assessed baroreflex sensitivity noninvasively from covariations of systolic pressure and RR interval using spectral analysis and sequence detection. The noninvasive estimates of baroreflex control were compared with estimates derived from phenylephrine-induced increases in systolic pressure and RR interval in normotensive subjects (n=27) and borderline hypertensive subjects (n=15). Baroreflex sensitivity was significantly reduced in the borderline hypertensive group relative to the normotensive group when assessed with the use of either the noninvasive or invasive methods to index baroreflex control. In addition, estimates obtained from the noninvasive methods were significantly correlated with baroreflex sensitivity assessed with the phenylephrine method (spectral:r=.48,P<.001; sequence:r=.50,P<.001). These findings suggest that spectral analysis and the sequence method provide viable alternatives to the pharmacological approach for estimation of baroreflex sensitivity in hypertension.