Resident Macrophages in Cystic Kidney Disease.
Resident Macrophages in Cystic Kidney Disease.
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DOI：
10.34067/kid.0006052020
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发表时间：
2021-01-28
期刊：
影响因子：
--
通讯作者：
Yoder BK
中科院分区：
文献类型：
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作者：
Li Z;Zimmerman KA;Yoder BK
间质炎症是囊性肾病的一个重要特征。肾巨噬细胞是肾脏中研究最多的炎性细胞，在不同的动物模型和囊性肾脏病患者中已有报道，它们参与了囊性病变的形成。最初，人们认为肾脏巨噬细胞是从骨髓来源的循环单核细胞的持续供应中维持的，并可以在局部炎症反应中被招募到肾脏。然而，通过使用命运图方法，这一想法受到了挑战，因为它表明，在成年小鼠的肾脏中，至少存在两种不同的巨噬细胞发育来源。第一种类型，浸润性巨噬细胞，从循环单核细胞中招募，并在进入肾脏后逐渐形成巨噬细胞特性。第二种是常驻巨噬细胞，主要起源于胚胎前体，在肾脏发育过程中定植，并在原位增殖，以维持其整个成年期的数量。浸润性巨噬细胞和驻留巨噬细胞共同作用，以维持体内平衡，并对病理情况做出适当反应，如AKI、囊性肾脏疾病或感染。这篇综述将简要总结目前对驻留巨噬细胞在囊性肾脏疾病中的认识。
Interstitial inflammation is an important feature of cystic kidney disease. Renal macrophages are the most well-studied inflammatory cell in the kidney, and their involvement in cyst formation has been reported in different animal models and patients with cystic kidney disease. Originally, it was believed that renal macrophages were maintained from a constant supply of bone marrow–derived circulating monocytes, and could be recruited to the kidney in response to local inflammation. However, this idea has been challenged using fate-mapping methods, by showing that at least two distinct developmental origins of macrophages are present in the adult mouse kidney. The first type, infiltrating macrophages, are recruited from circulating monocytes and gradually develop macrophage properties on entering the kidney. The second, resident macrophages, predominantly originate from embryonic precursors, colonize the kidney during its development, and proliferate in situ to maintain their population throughout adulthood. Infiltrating and resident macrophages work together to maintain homeostasis and properly respond to pathologic conditions, such as AKI, cystic kidney disease, or infection. This review will briefly summarize current knowledge of resident macrophages in cystic kidney disease.