The correspondence between coronary arterial wall strain and histology in a porcine model of atherosclerosis.
The correspondence between coronary arterial wall strain and histology in a porcine model of atherosclerosis.
复制标题
猪动脉粥样硬化模型中冠状动脉壁应变与组织学之间的对应关系。
DOI：
10.1088/0031-9155/54/18/018
复制
发表时间：
2009
影响因子：
3.5
通讯作者：
Friedman,MortonH
中科院分区：
文献类型：
--
作者：
Liang,Yun;Zhu,Hui;Friedman,MortonH
动脉粥样硬化斑块破裂是心血管疾病死亡的主要原因。血管内超声（IVUS）成像是一种强大的临床技术，可提供动脉壁和动脉粥样硬化斑块的实时横截面图像。然而，它没有提供足够的信息，斑块的组织学组成，以表征其脆弱性。动脉壁应变测量可以提供斑块组成和易损性的见解，补充IVUS回声图中直接可用的信息。我们已经开发了一种方法来测量横向动脉壁应变张量响应管腔压力的变化，通过注册IVUS图像采集在不同的压力。该方法已通过使用具有模拟运动的IVUS图像和血管体模的IVUS图像进行了验证。在这项研究中，我们进一步评估的方法，通过评估计算的应变分布和组织学组成的Sinclair小型猪动脉粥样硬化冠状动脉12个月的高脂肪饮食的对应关系。使用临床IVUS系统在计算机控制的加压下原位采集图像。图像采集后，固定动脉段进行组织学检查，以识别斑块成分。应变分布与相应的组织学切片一致。从壁应变分布推断的病变的各种组件的刚度与组织学横截面中观察到的组织组成一致。这些发现表明，血管内超声的应变测量有希望评估斑块的脆弱性。
Atherosclerotic plaque rupture is the leading cause of mortality in cardiovascular disease. Intravascular ultrasound (IVUS) imaging is a powerful clinical technique that provides real-time cross-sectional images of the arterial wall and atherosclerotic plaques. However, it does not provide sufficient information about the histological composition of plaques to characterize their vulnerability. Arterial wall strain measurements may provide insights into plaque composition and vulnerability, complementing the information directly available in the IVUS echogram. We have developed a method to measure the transverse arterial wall strain tensor in response to luminal pressure change, by registering IVUS images acquired at different pressures. This method has been validated by using IVUS images with simulated motion and IVUS images of a vessel phantom. In this study, we further evaluate the method by assessing the correspondence of the calculated strain distribution and the histological composition of atherosclerotic coronary arteries from Sinclair miniature pigs following 12 months of a high fat diet. The images were acquired in situ using a clinical IVUS system and under computer-controlled pressurization. After image acquisition, the artery segments were fixed for histology to identify plaque components. The strain distributions were aligned with the corresponding histological sections. The stiffness of various components of the lesion, inferred from the wall strain distribution, was consistent with the tissue composition seen in the histological cross-sections. These findings suggest that strain measurements from IVUS are promising for assessing plaque vulnerability.