Enantioselective Friedel-Crafts Reactions in Water Using a DNA-Based Catalyst
Enantioselective Friedel-Crafts Reactions in Water Using a DNA-Based Catalyst
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DOI：
10.1002/anie.200900371
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Roelfes, Gerard
中科院分区：
文献类型：
--
作者：
Boersma, Arnold J.;Feringa, Ben L.;Roelfes, Gerard
第一个例子是路易斯酸催化水中的不对称Friedel-Craft烷基化反应。在α，β-不饱和2-酰基咪唑与杂芳族π 亲核试剂的反应中，使用负载量为0.15摩尔 %的DNA基铜催化剂，获得了较高的产率和良好的对映选择性。Dmbpy=4，4‘-二甲基-2，2’-联吡啶。
Taking the plunge: The first example of a Lewis acid catalyzed asymmetric Friedel–Crafts alkylation with olefins in water is described. By using loadings of a DNA‐based copper catalyst as low as 0.15 mol %, good yields and excellent enantioselectivities were obtained in the reaction of α,β‐unsaturated 2‐acyl imidazoles with heteroaromatic π nucleophiles. dmbpy=4,4′‐dimethyl‐2,2′‐bipyridine.