Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features
Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features
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DOI：
10.1038/modpathol.2012.61
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发表时间：
2012-08-01
期刊：
影响因子：
7.5
通讯作者：
Pai, Reetesh K.
中科院分区：
文献类型：
--
作者：
Chang, Daniel T.;Pai, Rish K.;Pai, Reetesh K.
最近的文献表明，年轻患者的结肠直肠癌发病率增加。我们对散发性早发性（40岁）患者进行了组织学、分子和免疫表型分析。从2000年到2010年，共手术切除了1160例原发性结直肠腺癌。其中，75例（6%）诊断为40岁以下的患者。早发性结直肠癌组中，大多数病例（33/55，60%）在35 - 40岁之间被诊断。早发性结直肠癌组与对照组相比，肿瘤部位差异有显著性（P
Recent literature suggests an increasing incidence of colorectal carcinoma in young patients. We performed a histologic, molecular, and immunophenotypic analysis of patients with sporadic early-onset (40 years of age. A total of 1160 primary colorectal adenocarcinomas were surgically resected for the years 2000 through 2010. Of these, 75 (6%) were diagnoses in patients 40 years of age. For the early-onset colorectal carcinoma group, most cases (33/55, 60%) were diagnosed between the age of 35 and 40 years of age. Compared with the control group, the early-onset colorectal carcinoma group was significantly different with respect to tumor location (P